Results 71 to 80 of about 1,232,124 (326)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Assurer la sécurité alimentaire dans un contexte de changement climatique : un défi collectif

Oléagineux, Corps gras, Lipides, 2013
There is an urgent need to renew our agricultural model: 1 billion people still suffer from starvation nowadays, we are running short with fossile resources and climate change is already transforming agriculture throughout the World.
Guillou Marion
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

FEATURES OF BANK INSURANCE IN RUSSIA: PROTECTION OF INTERESTS OF COMPLEX FINANCIAL SERVICES CONSUMERS

Russian Journal of Economics and Law, 2013
Objective: To define the features of selling insurance products by banks in Russia. Methods: abstract-logical method. Results: Basing on the detailed analysis of bank insurance product “collective insurance of borrower’s life by the bank”, the problems ...
Z. V. Pisarenko
doaj  

Reviewing the Effect of Administrative Corruption on Financial Health in Iranian Banking System [PDF]

پژوهشهای اقتصادی, 2020
The banking industry is an important part of the economies. The health of the banking system as main policy-making channel and the foundation of the economic system is of great importance.
Mahdi Ghaemi Asl, Firooz Valaei
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The activities of the Commission for Traveling Abroad under the Smolensk Regional Committee of the CPSU in the late 1980s

Studia Humanitatis
The paper considers the activities of the Commission for Traveling Abroad operated under the Smolensk Regional Committee of the CPSU (Communist Party of the Soviet Union) in the second half of the 1980s.
Ivanov Alexander Mikhailovich, Silina Karina Vladimirovna   +1 more
doaj  

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

The Lancet, 2020
G. Livingston, Jonathan Huntley, A. Sommerlad, D. Ames, C. Ballard, Sube Banerjee, C. Brayne, A. Burns, J. Cohen-Mansfield, C. Cooper, S. Costafreda, A. Dias, Nick C Fox, L. Gitlin, R. Howard, H. Kales, M. Kivimäki, E. Larson, A. Ogunniyi, V. Orgeta, K. Ritchie, K. Rockwood, E. Sampson, Quincy M. Samus, L. Schneider, G. Selbæk, L. Teri, N. Mukadam   +27 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source