Results 91 to 100 of about 609,392 (314)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Reforming UK labour regulation in or outside the EU would be hard work [PDF]

open access: yes, 2015
Steve Coulter of the LSE outlines discussions during the recent session on labour markets of the LSE’s Commission on Britain in Europe, a major evidence-led inquiry looking at Britain’s future in the European Union in the light of the approaching ...
Coulter, Steve
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

The Diversity of Truth Commissions and Commissions of Inquiry

open access: yes, 2012
Over the past several decades, dozens of countries have established truth commissions and other bodies to investigate mass atrocities or systematic human rights abuse. Lessons learned from past truth-finding processes are invaluable to help address the legacies of human rights violations in countries transitioning to democratic regimes in the Middle ...
openaire   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Exploring factors hindering performance of information systems in the South African public sector – evidence from the Zondo Commission

open access: yesСистемный анализ и прикладная информатика
This article seeks to ascertain issues in the Commission of Inquiry popularly known as the Zondo Commission that consequently hinder and impede the performance of information systems in the South African public sector.
Ashley Latchu, Shawren Singh
doaj   +1 more source

Cape Melville affair coverage: what is news? [PDF]

open access: yes, 1995
Many observers saw coverage of the so-called Cape Melville affair as a post-Fitzgerald litmus test of the Brisbane media's watchdog duties with a government regarded as popular and competent. But who was watching the watchdogs? Conflicting news judgments
Conley, David, Turner, Geoff
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Regulating social problems: the pokies, the Productivity Commission and an Aboriginal Community [PDF]

open access: yes, 2004
Australia has 21 per cent of the world’s electronic gaming machines—more commonly known as poker machines. Deregulation of the industry has expanded the availability of gaming machines to an extent unprecedented in the western world.
Brady, Margaret
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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