Results 71 to 80 of about 609,392 (314)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Spreadsheet-Enhanced Problem Solving in Context as Modeling
Spreadsheets in Education, 2002 This paper is prompted by a recent call by the International Commission on Mathematical Instruction (ICMI) for the study of mathematical modeling as technology-enhanced didactic inquiry into relations between mathematics and the real world.
Sergei Abramovich
doaj +1 more source
Social determinants of health: Closing the gap in primary health care [PDF]
, 2013 Australian primary health care has a major role to play in addressing social determinants of health (SDOH). This RESEARCH ROUNDup examines the relevance of the Closing the gap in a generation report of the World Health Organization's Commission on Social
Raven, Melissa
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
National inquiry into children in immigration detention 2014: discussion paper [PDF]
Introduction: The purpose of this inquiry is to investigate the ways in which life in immigration detention affects the health, well-being and development of children. The inquiry will assess the impact on children by seeking the views of people who were
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Book Review of Village Journey by Thomas R. Berger [PDF]
, 1985 This review is as submitted to the Tundra Times. A revised version of the review, as edited by Tundra Times editorial staff, was published as "Doctrinal Overload Flaws Berger's 'Village Journey'" by Stephen Conn, Tundra Times, 23 Sep 1985, pp. 7, 11–12.
Conn, Stephen
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
La mobilisation autour des « atrocités de l'ennemi », Russie 1914-1918
Les Cahiers de Framespa, 2012 In Russia, on April 9th, 1915, the tsarist government asked senator A.N. Krivtsov to organize an Extraordinary Inquiry Commission in order to "investigate cases of violation by the German and Austro-Hungarian (and later Turkish) enemies of the laws and ...
Alexandre Sumpf
doaj +1 more source
Gas models and three difficult objectives [PDF]
Competition, security of supply and sustainability are at the core of EU energy policy. The Commission argues that making the European gas market more competitive (completing the internal gas market) will be instrumental in the pursuit of these ...
SMEERS, Yves
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FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source