Results 71 to 80 of about 8,961 (261)
The CUORE and CUORE-0 experiments at LNGS
EPJ Web of Conferences, 2017 The Cryogenic Underground Observatory for Rare Events (CUORE) is a 1-ton scale bolometric experiment devoted to the search of the neutrinoless double-beta decay (0νββ) in 130Te.D’Addabbo A., Alduino C., Alfonso K., Artusa D. R., Avignone F. T., Azzolini O., Banks T. I., Bari G., Beeman J.W., Bellini F., Bersani A., Biassoni M., Branca A., Brofferio C., Bucci C., Camacho A., Caminata A., Canonica L., Cao X. G., Capelli S., Cappelli L., Carbone L., Cardani L., Carniti P., Casali N., Cassina L., Chiesa D., Chott N., Clemenza M., Copello S., Cosmelli C., Cremonesi O., Creswick R. J., Cushman J. S., Dafinei I., Davis C. J., Dell’Oro S., Deninno M. M., Di Domizio S., Di Vacri M. L., Drobizhev A., Fang D. Q., Faverzani M., Fernandes G., Ferri E., Ferroni F., Fiorini E., Franceschi M. A., Freedman S. J., Fujikawa B. K., Giachero A., Gironi L., Giuliani A., Gladstone L., Gorla P., Gotti C., Gutierrez T. D., Haller E. E., Han K., Hansen E., Heeger K. M., Hennings-Yeomans R., Hickerson K. P., Huang H. Z., Kadel R., Keppel G., Kolomensky Yu. G., Leder A., Ligi C., Lim K. E., Liu X., Ma Y. G., Maino M., Marini L., Martinez M., Maruyama R. H., Mei Y., Moggi N., Morganti S., Mosteiro P. J., Napolitano T., Nones C., Norman E. B., Nucciotti A., O’Donnell T., Orio F., Ouellet J. L., Pagliarone C. E., Pallavicini M., Palmieri V., Pattavina L., Pavan M., Pessina G., Pettinacci V., Piperno G., Pira C., Pirro S., Pozzi S., Previtali E., Rosenfeld C., Rusconi C., Sangiorgio S., Santone D., Scielzo N.D., Singh V., Sisti M., Smith A. R., Taffarello L., Tenconi M., Terranova F., Tomei C., Trentalange S., Vignati M., Wagaarachchi S. L., Wang B. S., Wang H. W., Wilson J., Winslow L. A., Wise T., Woodcraft A., Zanotti L., Zhang G. Q., Zhu B. X., Zimmermann S., Zucchelli S. +124 moredoaj +1 more sourceInvestigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post +3 morewiley +1 more sourceCommissioning of ThomX Compton source subsystems and demonstration of 10^{10} x-rays/s
Physical Review Accelerators and BeamsThomX is a compact x-ray source based on Compton scattering, installed at IJCLab (Laboratoire de physique des 2 infinis-Irène Joliot-Curie) in Orsay.Muath Alkadi, Manuel Alves, Manar Amer, Loic Amoudry, Didier Auguste, Jean-Luc Babigeon, Michel Baltazar, Alain Benoit, Alexandre Blin, Marco Bonanzingamarco, Jean Bonenfant, Julien Bonis, Jean-Pierre Brasile, Kevin Cassou, Jean-Noël Cayla, Thomas Chabaud, Iryna Chaikovska, Sophie Chance, Vincent Chaumat, Ronic Chiche, Patrick Cornebise, Olivier Dalifard, Nicolas Delerue, Remy Dorkel, Denis Douillet, Illya Drebot, Jean-Phillipe Dugal, Kevin Dupraz, Noureddine El Kamchi, Mohamed El Khaldi, Ezgi Ergenlik, Pierre Favier, Marco Fernandez, Alexis Gamelin, Jean-Francois Garaut, Luca Garolfi, Philippe Gauron, Frédéric Gauthier, Alexandre Gonnin, Denis Grasset, Eric Guerard, Hayg Guler, Jacques Haissinski, Emmanuel Herry, Gregory Iaquaniello, Marie Jacquet, Didier Jehanno, Eric Jules, Viacheslav Kubytskyi, François Labaye, Mickaël Lacroix, Marc Langlet, Titouan Lebarillec, Jean-François Ledu, Damien Le Guidec, Bruno Leluan, Pierre Lepercq, Frédéric Letellier-cohen, Rodolphe Marie, Jean-Claude Marrucho, Aurélien Martens, Christophe Mageur, Gabriel Mercadier, Bruno Mercier, Eric Mistretta, Hugues Monard, Alexandre Moutardier, Viktor Mytrochenko, Olivier Neveu, Daniele Nutarelli, Maher Omeich, Yann Peinaud, Antoine Pérus, Yannick Petrilli, Marc Pichet, Bernard Pieyre, Eric Plaige, Christophe Prévost, Thomas Roulet, Raphael Roux, Philippe Rudnicky, Viktor Soskov, Monique Taurigna-Quéré, Stéphane Trochet, Cynthia Vallerand, Alessandro Variola, Olivier Vitez, François Wicek, Guy Wormser, Sébastien Wurth, Fabian Zomer, Patrick Alexandre, Rachid Ben el Fekih, Philippe Berteaud, Sébastien Bobault, Yazid Bouanani, François Bouvet, Lodovico Cassinari, Marie-Emmanuelle Couprie, Renaud Cuoq, Helder Dias, Yannick Dietrich, Massamba Diop, Eric Dupuy, Moussa El Ajjouri, Christian Herbeaux, Nicolas Hubert, Marie Labat, Alain Lestrade, Antoine Letrésor, Robert Lopes, Alexandre Loulergue, Patrick Marchand, Fabrice Marteau, Didier Muller, Amor Nadji, Laurent Nadolski, Ryutaro Nagaoka, Dominique Pedeau, Sylvain Petit, Jean Pierre Pollina, Fernand Ribeiro, Manuel Ros, Julien Salvia, Mourad Sebdaoui, Rajesh Sreedharan, Jean Susini, José Veteran, Cyril Bruyere, Alain Cobessi, William Del Net, Jean-Louis Hazemann, Jean-Louis Hodeau, Philippe Jacquet, Philippe Jeantet, Grigor Kapoujyan, Jérôme Lacipière, Eric Lahéra, Gilles Perroux, Olivier Proux, Emmanuel Roy, Philippe Walter, Alberto Bravin, Hélène Elleaume, François Estève, Harold Bzyl, Christophe Chapelle, Jean-Michel Horodynski, Pierre Robert, Eric Cormier, Jérôme Degallaix, Christophe Michel, Laurent Pinard, Philippe Balcou, Jérôme Lhermite, Sébastien Montant, Marie-Christine Nadeau, Stéphane Petit, Nikolay Artemiev, Marica Biagini, Romain Czarny, Pascal Girault, Sophie Muller, Serge Sierra, Christophe Simon-Boisson, Said Bouaziz, Chamseddine Benabderrahmane, Géraldine Le Duc, Xing Liu +168 moredoaj +1 more sourceEDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot +36 morewiley +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceSomatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen +5 morewiley +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceICRF heating schemes for the ITER non-active phase
EPJ Web of Conferences, 2017 ITER plasma operation requires a non-active phase for tokamak initial commissioning, covering First Plasma and Pre-Fusion Power Operation phases, PFPO-1 and PFPO-2.Schneider Mireille, Artaud Jean-François, Bonoli Paul, Kazakov Yevgen, Lamalle Philippe, Lerche Ernesto, Van Eester Dirk, Wright John +7 moredoaj +1 more source
