Results 41 to 50 of about 94,746 (270)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Remote preparation of arbitrary ensembles and quantum bit commitment

, 2004
The Hughston-Jozsa-Wootters theorem shows that any finite ensemble of quantum states can be prepared "at a distance", and it has been used to demonstrate the insecurity of all bit commitment protocols based on finite quantum systems without ...
Bub J., Cassinelli G., Keyl M., Schwartz J., Tomita M.   +4 more
core   +1 more source

Quantum Lightning Never Strikes the Same State Twice [PDF]

, 2017
Public key quantum money can be seen as a version of the quantum no-cloning theorem that holds even when the quantum states can be verified by the adversary.
B Barak, C Gentry, CH Bennett, CH Bennett, D Boneh, D Boneh, D Micciancio, D Unruh, D Unruh, J Ding, J-S Coron, MC Pena, MR Albrecht, R Cramer, S Garg, S Garg, S Wiesner, Y Chen   +17 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Regret Minimization in Partially Observable Linear Quadratic Control [PDF]

, 2020
We study the problem of regret minimization in partially observable linear quadratic control systems when the model dynamics are unknown a priori. We propose ExpCommit, an explore-then-commit algorithm that learns the model Markov parameters and then ...
Anandkumar, Anima, Azizzadenesheli, Kamyar, Hassibi, Babak, Lale, Sahin   +3 more
core   +1 more source

Keeping Authorities "Honest or Bust" with Decentralized Witness Cosigning [PDF]

, 2016
The secret keys of critical network authorities - such as time, name, certificate, and software update services - represent high-value targets for hackers, criminals, and spy agencies wishing to use these keys secretly to compromise other hosts.
Ford, Bryan, Gailly, Nicolas, Gasser, Linus, Jovanovic, Philipp, Khoffi, Ismail, Syta, Ewa, Tamas, Iulia, Visher, Dylan, Wolinsky, David Isaac   +8 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

An Extended Survey Concerning the Vector Commitments

Applied Sciences
Commitment schemes represent foundational cryptographic primitives enabling secure verification protocols across diverse applications, from blockchain systems to zero-knowledge proofs. This paper presents a systematic survey of vector, polynomial, and functional commitment schemes, analyzing their evolution from classical constructions to post-quantum ...
Maria Nutu, Giorgi Akhalaia, Razvan Bocu, Maksim Iavich   +3 more
openaire   +1 more source

War and endogenous democracy [PDF]

, 2008
Many episodes of extension of franchise in the 19th and especially in the 20th century occurred during or in the aftermath of major wars. Motivated by this fact, we offer a theory of political transitions which focuses on the impact of international ...
Ticchi, Davide, Vindigni, Andrea
core