Results 51 to 60 of about 94,746 (270)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Security Trade-offs in Ancilla-Free Quantum Bit Commitment in the Presence of Superselection Rules
, 2004 Security trade-offs have been established for one-way bit commitment in quant-ph/0106019. We study this trade-off in two superselection settings. We show that for an `abelian' superselection rule (exemplified by particle conservation) the standard trade ...
Barbara M Terhal +5 more
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A (Zero-Knowledge) Vector Commitment with Sum Binding and its Applications
The Computer Journal, 2019 Abstract Vector commitment (VC) schemes allow committing to an ordered sequence of ${q}$ values ${(m_1,\cdots ,m_q)}$ in such a way that one can later open the commitment at specific positions. However, the existing VC schemes suffer from two substantial shortcomings that limit their use: (i) the commitments cannot be opened except at ...
Zifeng Xu +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Concise Mercurial Vector Commitments and Independent Zero-Knowledge Sets with Short Proofs [PDF]
, 2010 Introduced by Micali, Rabin and Kilian (MRK), the basic primitive of zero-knowledge sets (ZKS) allows a prover to commit to a secret set S so as to be able to prove statements such as x∈S or $x \not\in S$. Chase et al. showed that ZKS protocols are underlain by a cryptographic primitive termed mercurial commitment. A (trapdoor) mercurial commitment has
Benoît Libert, Moti Yung
openaire +1 more source
Non-Committed Procurement under Intricate Uncertainty [PDF]
This paper studies asymmetric first-price menu auctions in the procurement environment where the buyer does not commit to a decision rule and asymmetric sellers have interdependent costs and statistically affiliated signals.
Seungjin Han
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source