Results 61 to 70 of about 2,301,735 (313)

A Tale of Two Europes: European Regions from Berlin to Lisbon

Australian and New Zealand Journal of European Studies, 2010
One of the lesser noted elements of the Lisbon Treaty (and Treaty on a Constitution for Europe that preceded it), was the limited but significant influence that Europe's regions were able to exert of the process. Regional successes at Lisbon included the
W. John Hopkins
doaj   +1 more source

The role of regional information in the optimal composition of a committee [PDF]

In this paper we present a model for the optimal composition of a federal or supra-national committee. The involvement of regional (national) entities in federal committees is typically motivated by their knowledge of regional information about the state
Beata K. Bierut, Philipp Maier, Robert-Paul Berben   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Do pro-poor schools reach out to the poor? Location choice of BRAC and ROSC schools in Bangladesh [PDF]

, 2016
Location choice of ‘one teacher, one classroom’ non-formal primary schools pioneered by Bangladesh Rural Advancement Committee (BRAC) is studied vis-à-vis its replication under government-managed Reaching-Out-of-School (ROSC) project using school Census ...
Ahmed, Andrabi, Arif, Asadullah, Asadullah, Asadullah, Asadullah, Asadullah, Barr, Brass, Chabbott, Chabbott, Chowdhury, Coombs, Downes, Downes, Essuman, Evans, Farrell, Fruttero, Glaeser, Kabeer, Khan, Li, McEwan, Pal, Psacharopolous, Ravallion, Sharma, Smith, Sud, Werker   +31 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Participation in higher education: A geodemographic perspective on the potential for further expansion in student numbers [PDF]

Higher Education in England has expanded dramatically in the last ten years with the result that currently more than 30 per cent of young people go on to University. This upward trend in the participation rate is almost certain to continue, following the
Peter Batey, Peter Brown
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Ural Bureau of the Central Committee of the RCP(b) and the Creation of Ural Oblast in 1923

Известия Уральского федерального университета. Серия 2: Гуманитарные науки
This article analyses the activities of the Ural Bureau of the Central Committee of the RCP(b) in the preparation and implementation of measures for the zoning of the Urals within the framework of the administrative-territorial reform of 1923.
Sergey Viktorovich Vorobyov
doaj   +1 more source