ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Transcript-Specific DNA Methylation Alterations of the RASSF1 Locus in Cancer Cells. [PDF]
Bermudez LG +8 more
europepmc +1 more source
COMMUNICATION FROM THE COMMISSION TO THE COUNCIL, THEEUROPEAN PARLIAMENT, THE EUROPEAN ECONOMIC AND SOCIALCOMMITTEE, THE COMMITTEE OF THE REGIONS AND THE EUROPEANCENTRAL BANK. Fourth report on the practical preparations for the future enlargement of the euro area. COM(2006) 671 final, 10 November 2006 [PDF]
openalex
Equality between women and men 2005. Report from the Commission to the Council, the European Parliament, the European Economic and Social Committee and the Committee of the Regions. COM (2005) 44 final, 14 February 2005 [PDF]
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ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
Whispers of decay: necrotic mediastinal lymphadenopathy due to melioidosis in a diabetic patient. [PDF]
Kamath R +4 more
europepmc +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification. [PDF]
Pinto JEL +10 more
europepmc +1 more source
Life sciences and biotechnology – A strategy for Europe. Communication from the Commission to the Council, the European Parliament, the European Economic and Social Committee and the Committee of the Regions. COM (2002) 27 final, 23 January 2002 [PDF]
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