Results 151 to 160 of about 7,321,229 (297)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Understanding HIV epidemiology: a comprehensive analysis of demographic, clinical, and virological profiles of patients with HIV at a tertiary care center. [PDF]

IJID Reg
Abdou HA, Khamis F, Sherif M, Naamani JA, Bahrani KA, Alyaaqoubi A, Awaidy STA.   +6 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Common-mode voltage suppression for traction drive systems based on carrier phase shift control

机车电传动
To suppress the common mode voltage generated by the traction system due to inverter pulse-width modulation (PWM) and to reduce electrical corrosion of the bearings and electromagnetic compatibility (EMC) interference, this paper proposes a strategy for ...
ZHANG Ying, WANG Chenfan, CHEN Ke, HU Xian, HOU Zhaowen, WANG Wentao   +5 more
doaj  

Factors associated with viral suppression and antiretroviral therapy adherence among adolescents and young adults living with HIV in the African Cohort Study. [PDF]

J Acquir Immune Defic Syndr
Brault MA, Brault MA, Ahonkhai AA, Frndak S, Colt S, Crowell TA, Parikh A, Duff ER, Sing'oei V, Owuoth J, Maswai J, Parker Z, Bahemana E, Kibuuka H, Vermund SH, Shah N, Ake JA, AFRICOS Study Group.   +17 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Improving forward identified hadron spectra in proton carbon collisions at 90 GeV/c using impact parameter dependent subcollision acceptance in PYTHIA 8 Angantyr. [PDF]

Sci Rep
Felemban N, Abdel-Waged K.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Breaking the phase noise-mode purity trade-off in long-loop OEOs via cascaded zero-dispersion recirculating loops. [PDF]

Light Sci Appl
Wang Z, Bernal S, Plant DV, Chen LR.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source