Results 141 to 150 of about 3,027 (217)

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

New boost type single phase inverters for photovoltaic applications with reduced device count. [PDF]

PLoS One
Alaas ZM.
europepmc   +1 more source

Entrepreneurial Orientation and Knowledge‐Driven Innovation

Knowledge and Process Management, EarlyView.
ABSTRACT The expansion of the knowledge‐based economy has driven rapid growth in the literature on knowledge management (KM) and intellectual capital (IC), covering topics such as learning, business, and innovation. Scholars recognize knowledge as a significant resource that can foster innovation to attain a competitive advantage.
Fahad Aljaeed, Nasser Alqahtani, Basma Khoja   +2 more
wiley   +1 more source

Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator. [PDF]

J Med Device
Cruz AF, Herrmann J, Hajdarevic B, Hawley ML, Fox D, Bates JHT, Kaczka DW.   +6 more
europepmc   +1 more source

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Med Research, EarlyView.
A schematic diagram illustrating the KMT5C‐H4K20me3‐EWSR1‐ACADM signaling axis and its role in ccRCC progression. Key Outcomes: KMT5C/H4K20me3 are upregulated in ccRCC and predict poor prognosis. EWSR1 is a novel noncanonical H4K20me3 reader in ccRCC. KMT5C/EWSR1 co‐repress ACADM via transcription and m6A modification. A‐196 + sunitinib synergistically
Chengjian Ji, Da Zhong, Tian Rao, Xiaojun Li, Weiyu Kong, Xi Zhang, Xiyi Wei, Bing Yao, Xinqiang Li, Ninghong Song, Chao Qin   +10 more
wiley   +1 more source

Pilot longitudinal integrated transcriptomic-metabolomic study reveals immune and metabolic signatures in non-hospitalized healthcare workers with long COVID. [PDF]

Front Cell Infect Microbiol
Espín E, Yang C, Shannon CP, Checkervarty AK, Kim S, Lapp L, Assadian S, Grunau B, Goldfarb DM, Hutton J, Huan T, Tebbutt SJ.   +11 more
europepmc   +1 more source

An open‐source pipeline for longitudinal single‐cell tracking and cell‐cycle/migration coupling analysis for neurotherapeutic screening

Neuroprotection, EarlyView.
Integrated experimental and computational pipeline for longitudinal single‐cell tracking and cell‐cycle dynamics analysis. Schematic of the FUCCI (Fluorescence Ubiquitination‐based Cell Cycle Indicator) reporter system. The construct is driven by the CAG promoter (CMV enhancer + chicken β‐actin promoter) and encodes two fusion proteins: mKO2‐Cdt1 ...
Neha Chandra, Matthew Yang, Hailey Wang, Miroslaw Janowski, Piotr Walczak, Cedric Allier, Yajie Liang   +6 more
wiley   +1 more source

Phase disposition PWM control topology based: A novel multilevel inverter with reduced switch for power electronics applications. [PDF]

Heliyon
Y VS, R V.
europepmc   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

A Framework for Evaluation of New Processing Technologies in Human Milk Banking. [PDF]

Compr Rev Food Sci Food Saf
Clifford V, Walter L, Klein LD, Wu T, Wang Y, Bansal N.   +5 more
europepmc   +1 more source