Results 81 to 90 of about 3,027 (217)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Real-Time Optimization Strategy to Minimize Switching Losses for Three-Level NPC Inverter

This paper proposes a real-time optimization strategy, aimed at minimizing switching losses in a three-level neutral-point-clamped (3L-NPC) inverter.
Li, Kai, Xie, Chuan, Guerrero, Josep M.; id_orcid, Wei, Min, Vasquez, Juan C.; id_orcid, Deng, Fujin; id_orcid   +5 more
core   +1 more source

Investigation of the Common Mode Voltage for a Neutral-Point-Clamped Multilevel Inverter Drive and its Innovative Elimination through SVPWM Switching-State Redundancy

, 2016
The purpose of this paper is to provide a comprehensive Investigations and its control on the common mode Voltage (CMV) of the three-phase three-level neutral-point diode-clamped (NPC) multilevel inverter (MLI).
Munda, J.L., Navaneesh, T Sai, Bharatiraja, C., Sriramsai, N.   +3 more
core   +2 more sources

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Investigation and Comparative Analysis of Advanced PWM Techniques for Three-Phase Three-Level NPC-MLI Drives

, 2018
The Multilevel inverter topologies (MLIs) are increasingly being used, which is the preferred choice in many industrial Medium-voltage (MV) applications.
Chokkalingham, Bharatiraja, Sanjeevikumar Padmanaban, Bharatiraja Chokkalingham, Padmanaban, Sanjeevikumar, Blaabjerg, Frede; id_orcid, Frede Blaabjerg   +5 more
core   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Design of Active Common Mode Noise Voltage Canceler for SiC Inverter Fed Induction Motor Drive with Reduced Common Mode Voltage PWM

This paper presents the design of active common mode noise voltage canceler (ACVC) for induction motor drive with active zero vector pulse width modulation (AZPWM-1).
Kumar, Manish, Jayaraman, Kalaiselvi
core   +1 more source

Control of Indirect Matrix Converter by Using Improved SVM Method

, 2015
<span style="font-family: &quot;TimesNewRoman,Bold&quot;,&quot;Arial&quot;; font-size: 9pt;">A novel space vector modulation (SVM) method for an indirect matrix converter (IMC) is used to reduce the common -mode voltage (CMV) in
Lavanya Nannapaneni, Venu Gopala Rao
core   +2 more sources