Results 71 to 80 of about 10,526,019 (294)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Conservative management of unicystic ameloblastoma in a young child: Report of two cases

Contemporary Clinical Dentistry, 2011
Unicystic ameloblastoma is a rare, benign, locally invasive odontogenic neoplasm of young age that show clinical, radiographic, or gross features of an odontogenic cyst, but histologically shows typical ameloblastomatous epithelium lining part of the ...
Ritesh Kalaskar, Ashok S Unawane, Ashita R Kalaskar, Prashant Pandilwar   +3 more
doaj   +1 more source

Russia and the European Union: an elusive quest for common values? [PDF]

Baltic Region, 2012
This article focuses on the dialogue between the Russian Federation and the European Union based on “common values” (legal sphere and the rule of law), which form the framework for the EU-Russia “common spaces” — on the economy, freedom, security and ...
Ryngaert Cedric
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Consistency as an Issue in EU External Activities. EIPA Working Paper 99/W/06 [PDF]

, 1999
[From the Introduction]. The European Community (EC) was initially only competent in the area of trade and gradually developed a common commercial policy. The 1970s onwards saw increasing foreign policy co-operation in the framework of European Political
Duke, Simon
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Scope of application of the generał rule in the Rome II Regulation

Acta Iuris Stetinensis, 2020
The purpose of the paper is to determine the scope of application of Article 4(1), which con- stitutes the general rule of the Rome II Regulation concerning the law applicable to non- contractual obligations.
Magdalena Wasylkowska-Michór
doaj   +1 more source

Common Article 3 and Asymmetric Warfare in the Context of Cyber Operations

Pakistan Journal of Criminal Justice
International Humanitarian Law (IHL) serves as the crucial framework governing armed conflicts, seeking to humanize warfare and regulate the conduct of hostilities, whether at the international or non-international level. While the rules outlined in Common Article 3 (CA3) and Additional Protocol II (APII) pertain specifically to non-international armed
null Muhammad Asif Safdar, null Dr. Faiz Bakhsh, null Saadat Ali Nadeem, null Prof. Dr. Rao Imran Habib   +3 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source