Results 291 to 300 of about 279,538 (412)

Non‐Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In a multi‐centre study of obeticholic acid in primary biliary cholangitis, 45% discontinued the drug over 4 years, with 11% moving to combination therapy (fibrates). Of those continuing, response rates increased from 37% (1 year) to 55% (4 years). Non‐response at 12 months and cirrhosis were independent predictors of liver‐related events.
Nadir Abbas   +18 more
wiley   +1 more source

A Population‐Based Matched Cohort Study of Extra‐Digestive Cancer Incidence and Mortality in Individuals With and Without Inflammatory Bowel Disease

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
This illustration summarises our primary findings highlighting the rising incidence of certain extra‐digestive cancers among persons with IBD over the 25‐year study duration (left), and the relative rates of extra‐digestive cancer incidence and mortality among persons with IBD in recent years (2010–2019) compared to their age‐ and sex‐matched controls (
Sanjay K. Murthy   +13 more
wiley   +1 more source

A contemporary map of Fasciola hepatica distribution in sheep and cattle in New South Wales

open access: yesAustralian Veterinary Journal, EarlyView.
Fasciola hepatica is a global threat to livestock production, human health, and food security. Infection causes significant reductions in milk production and quality, feed conversion efficiency, wool quality, and reproductive performance. In New South Wales (NSW), Australia, data on the distribution of F. hepatica are more than 50 years out of date and
SN Vyas   +3 more
wiley   +1 more source

Common bile duct

open access: yes, 2013
Chia Wei Oh, Jeremy Jones, Tariq Walizai
openaire   +1 more source

Functional Difference of MYC and MYCN in Combined Hepatocellular–Cholangiocarcinoma: Regulation of Differentiation by HNF1B

open access: yesCancer Science, EarlyView.
Combined hepatocellular–cholangiocarcinoma (cHCC‐CCA) is a tumor consisting of a mixture of hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CCA) components, but the mechanisms of development are poorly understood. The activation of Myc may be implicated in the formation of cHCC‐CCA and this work demonstrates for the first time that Myc ...
Masanori Goto   +10 more
wiley   +1 more source

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