Results 91 to 100 of about 2,578,328 (266)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Establishing core data elements for colorectal cancer and mapping to FHIR resources: Towards interoperable Iranian health information systems

Journal of Education and Health Promotion
Background: Colorectal cancer (CRC) has a high prevalence, threatening public health. Despite the high prevalence, there has not been a proper solution to standardize the data in this domain in Iran.
Raoof Nopour, Somayeh Nasiri, Maryam Ahmadi, Mohammad Shirkhoda   +3 more
doaj   +1 more source

Common data elements and features of brucellosis health information management system

Informatics in Medicine Unlocked, 2022
Introduction: A key step in constructing any health information management system (HIMS) is to decide on a set of minimal yet comprehensive data items.
Mohsen Shafiee, Mostafa Shanbehzadeh, Hadi Kazemi-Arpanahi   +2 more
doaj  

Design, implementation, and inferential issues associated with clinical trials that rely on data in electronic medical records: a narrative review

BMC Medical Research Methodology, 2023
Real world evidence is now accepted by authorities charged with assessing the benefits and harms of new therapies. Clinical trials based on real world evidence are much less expensive than randomized clinical trials that do not rely on “real world ...
Alan Leviton, Tobias Loddenkemper
doaj   +1 more source

Common Data Elements for Concussion in Tertiary Care: Phase One in Ontario [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2017
AbstractBackground:Standardized data collection for traumatic brain injury (TBI) (including concussion) using common data elements (CDEs) has strengthened clinical care and research capacity in the United States and Europe. Currently, Ontario healthcare providers do not collect uniform data on adult patients diagnosed with concussion.Objective:The ...
Lisa Fischer, Deanna Quon, Michael D. Cusimano, Chantal Vaidyanath, Cindy Hunt, Alicja Michalak, Shree Bhalerao, Shawn Marshall, Cheryl Masanic, Donna Ouchterlony, Andrew J. Baker   +10 more
openaire   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Common data elements and data management: Remedy to cure underpowered preclinical studies

Epilepsy Research, 2017
Lack of translation of data obtained in preclinical trials to clinic has kindled researchers to develop new methodologies to increase the power and reproducibility of preclinical studies. One approach relates to harmonization of data collection and analysis, and has been used for a long time in clinical studies testing anti-seizure drugs.
Lapinlampi, Niina, Melin, Esbjörn, Aronica, Eleonora, Bankstahl, Jens P., Becker, Albert, Bernard, Cristophe, Gorter, Jan A., Gröhn, Olli, Lipsanen, Anu, Lukasiuk, Katarzyna, Löscher, Wolfgang, Paananen, Jussi, Ravizza, Teresa, RONCON, Paolo, SIMONATO, Michele, Vezzani, Annamaria, Kokaia, Merab, Pitkänen, Asla   +17 more
openaire   +7 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Data harmonization and common data elements

, 2019
Presentation at Planning a Virtual Down Syndrome Cohort Across the Lifespan Workshop, September 23–24, 2019, William F.
openaire   +1 more source

Common Data Elements for Neuroimaging of Traumatic Brain Injury: Pediatric Considerations [PDF]

Journal of Neurotrauma, 2012
As part of the Traumatic Brain Injury Common Data Elements project, a large-scale effort to define common data elements across a variety of domains, including neuroimaging, special considerations for pediatric patients were introduced. This article is an extension of that initial work, in which pediatric-specific pathoanatomical entities, technical ...
Barbara A. Holshouser, Ann-Christine Duhaime, Karen A. Tong, Jill V. Hunter   +3 more
openaire   +2 more sources