Results 161 to 170 of about 4,121,353 (304)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group. [PDF]

Neurocrit Care, 2023
Carroll EE, Der-Nigoghossian C, Alkhachroum A, Appavu B, Gilmore E, Kromm J, Rohaut B, Rosanova M, Sitt JD, Claassen J, Curing Coma Campaign and its Contributing Members.   +10 more
europepmc   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data. [PDF]

Neurocrit Care, 2023
Beqiri E, Badjatia N, Ercole A, Foreman B, Hu P, Hu X, LaRovere K, Meyfroidt G, Moberg D, Robba C, Rosenthal ES, Smielewski P, Wainwright MS, Park S, Curing Coma Campaign and its Contributing Members.   +14 more
europepmc   +1 more source

Analysis of Different Rare Metals, Rare Earth Elements, and other Common Metals in Groundwater of South West Bank/Palestine by ICP/MS-Data and Health Aspects

, 2013
Fuad Al‐Rimawi, Khalid Kanan, Mutaz Qutob   +2 more
openalex   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Recommendations for the National Institute for Neurologic Disorders and Stroke spinal cord injury common data elements for children and youth with SCI [PDF]

, 2016
M.J. Mulcahey, Lawrence C. Vogel, Muniza Sheikh, Juan Carlos Arango‐Lasprilla, Marika Augutis, Elizabeth O. Garner, Ellen Merete Hagen, Lyn B. Jakeman, Eleanor Kelly, Rebecca Martin, Joanne Odenkirchen, Anke Scheel‐Sailer, Jennifer Schottler, H Taylor, Christina Calhoun Thielen, Kathy Zebracki   +15 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Kolmogorov-Smirnov Tests For Distribution Function Similarity With Applications To Portfolios of Common Stock [PDF]

If the elements of the choice set in a decision model involving randomness are not arbitrary, but restricted appropriately, an expected utility ordering of them can be represented by a mean standard deviation ranking function.
Jack Meyer, Robert H. Rasche
core