Results 171 to 180 of about 4,121,353 (304)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot: Multicenter Implementation of the Common Data Elements for Traumatic Brain Injury

, 2013
John K. Yue, Mary J. Vassar, Hester F. Lingsma, Shelly R. Cooper, David O. Okonkwo, Alex B. Valadka, Wayne A. Gordon, Andrew I.R. Maas, Pratik Mukherjee, Esther L. Yuh, Ava M. Puccio, David M. Schnyer, Geoffrey T. Manley and TRACK-TBI Investigators, Scott S. Casey, Maxwell Cheong, Kristen Dams-O’Connor, Allison J. Hricik, Emily E. Knight, Edwin Kulubya, David Menon, Diane Morabito, Jennifer Pacheco, Tuhin Sinha   +22 more
openalex   +1 more source

tbiExtractor: A framework for extracting traumatic brain injury common data elements from radiology reports [PDF]

, 2019
Margaret Y. Mahan, Daniel Rafter, Hannah Casey, Marta Engelking, Tessneem Abdallah, Charles L. Truwit, Mark Oswood, Uzma Samadani   +7 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Development and implementation of the National Heart, Lung, and Blood Institute COVID-19 common data elements. [PDF]

J Clin Transl Sci, 2022
Weissman A, Cheng A, Mainor A, Gimbel E, Nowak K, Pan HH, Stratford J, Merkel A, Taylor C, Meier H, Auman J, Nolen TL, Lindsell CJ, Huang DT.   +13 more
europepmc   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Common data elements and minimum data sets in cerebral palsy: Start small to grow big. [PDF]

Dev Med Child Neurol, 2022
Dieterich K.
europepmc   +1 more source

Common data element

, 2019
Jay Gajera, Francis Deng
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source