Results 221 to 230 of about 5,507,168 (319)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Application of the Delphi method to the development of common data elements for social drivers of health: A systematic scoping review. [PDF]

Transl Behav Med
Levites Strekalova YA, Nelson JD, Weber HM, Wang X, Midence SM.   +4 more
europepmc   +1 more source

Review of Key Elements in Developing a Common Data Model for Rare Diseases: Identifying Common Success Factors [PDF]

Adam S.L. Graefe, Filip Rehburg, Miriam Hübner, Sylvia Thun, Oya Beyan   +4 more
openalex   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Multicenter Validation of Natural Language Processing Algorithms for the Detection of Common Data Elements in Operative Notes for Total Hip Arthroplasty: Algorithm Development and Validation.

JMIR Med Inform, 2022
Han P, Fu S, Kolis J, Hughes R, Hallstrom BR, Carvour M, Maradit-Kremers H, Sohn S, Vydiswaran VGV.   +8 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Common data elements for clinical research in mitochondrial disease: a National Institute for Neurological Disorders and Stroke project [PDF]

, 2017
Amel Karaa, Shamima Rahman, Anne Lombès, Patrick Yu‐Wai‐Man, Muniza Sheikh, Sherita Alai‐Hansen, Bruce H. Cohen, David Dimmock, Lisa Emrick, Marni J. Falk, Shana E. McCormack, David M. Mirsky, Tony Moore, Sumit Parikh, John M. Shoffner, Tanja Taivassalo, Mark A. Tarnopolsky, Ingrid Tein, Joanne Odenkirchen, Amy Goldstein   +19 more
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Determining the frequency of reporting laboratory data in summary sheets of patients in a pediatric ward based on the classification of diagnoses in ICD-10

Clinical Epidemiology and Global Health
Background: A summary of clinical findings and laboratory data is collected in patient summary sheets. The aim of this study was to determine the frequency of laboratory data reported in the summary sheets based on the classification of diagnoses in ICD ...
Farzaneh Shahbakhsh, Reza Khajouei, Azam Sabahi, Yousef Mehdipour, Leila Ahmadian   +4 more
doaj