Results 261 to 270 of about 817,831 (307)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Common Fixed Point Theorem for Expansive Mappings under Strict Implicit Conditions on b-Metric Spaces

, 2011
Mohamed Akkouchi
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

ARTreeFormer: A faster attention-based autoregressive model for phylogenetic inference. [PDF]

PLoS Comput Biol
Xie T, Mao Y, Zhang C.
europepmc   +1 more source

When the outcome is compositional: A method for conducting compositional response linear mixed models for physical activity, sedentary behaviour and sleep research. [PDF]

PLoS One
Miatke A, Stanford T, Olds T, Fraysse F, Maher C, Martin-Fernandez JA, Dumuid D.   +6 more
europepmc   +1 more source

Anatomic Medial Collateral Ligament, Posterior Oblique Ligament, and Double-Bundle Posterior Cruciate Ligament Reconstructions With Concomitant Distal Femoral Osteotomy in the Setting of a Chronic Injury. [PDF]

Arthrosc Tech
Behnke RA, Smith KH, Lee DR, Rasmussen MT, Wilebski BJ, Tollefson LV, LaPrade RF.   +6 more
europepmc   +1 more source

Similarity-aware VAE with wavelet-convolutional 1D-CNN for rolling bearing fault diagnosis. [PDF]

PLoS One
Xiong W, Xiao N, Wang R.
europepmc   +1 more source

A Common Fixed Point Theorem

A Common Fixed Point Theorem
openaire