Results 211 to 220 of about 2,254,732 (262)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A review of attitudes towards the reuse of health data among people in the European Union: The primacy of purpose and the common good.

Health Policy, 2019
Skovgaard LL, Wadmann S, Hoeyer K.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

[For the common good].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008
openaire   +1 more source

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For the Common Good

Computer, 2013
We don't have satisfactory answers to questions that ask what we must share with our neighbor for our common good and the rights we retain in the process. Yet such answers will be the legacy of our age. The Web extra at http://youtu.be/U0piYSt35YU is a video segment in which author David Alan Grier expands on his Errant Hashtag column, in which he ...
  +5 more sources

The Common Good [PDF]

SSRN Electronic Journal, 2011
The concept of the common good occupied a relevant place in classical social, political and economic philosophy. After losing ground in the Modern age, it has recently reappeared, although with different and sometimes confusing meanings. This paper is the draft of a chapter of a Handbook; it explains the meaning of common good in the Aristotelian ...
openaire   +1 more source

Wireless commons perils in the common good

Communications of the ACM, 2006
In the last few years, high-speed wireless access to the Internet has grown rapidly. Surprisingly, this growth has not come through cellular phone networks as many had expected, but through IEEE 802.11 standards-based wireless local area networks (WLANs).
Damsgaard, Jan, Parikh, Mihir A., Rao, Bharat   +2 more
openaire   +2 more sources