Results 231 to 240 of about 1,455,547 (299)

Making grandchildren. Is there an interest in becoming a grandparent? [PDF]

Med Health Care Philos
Cutas D.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Common infant product materials negatively impact breathing. [PDF]

Can J Respir Ther
Olvera HL, Bossert A, Koster M, Stover C, Mannen EM.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Health care crisis: looking beyond the obvious: Part 1: Understanding the forces at play. [PDF]

Can Fam Physician
Pilon MD, Holland T, Moreau M, Upshur REG, Simpson C, Buchman D.   +5 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Micro-costing analysis of a community-based psychiatric intervention among people who inject drugs in Haiphong, Vietnam. [PDF]

Front Psychiatry
Trouiller P, Le SM, Hoang Thi G, Duong Thi H, Khuat Thi Hai O, Nham Thi TT, Moles JP, Laureillard D, Des Jarlais DC, Nagot N, Michel L, Pelletier-Fleury N.   +11 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Cooperative environmental engineering via biofilm formation can stabilize consumer-resource systems. [PDF]

PLoS One
Lynn BK, De Leenheer P, Dalziel BD.
europepmc   +1 more source

Under-Five Undernutrition Prevalence, Its Inequality, Associated Socio-Economic and Demographic Factors in Uganda: Secondary Analysis of 2019/2020 National Panel Data. [PDF]

Nutr Metab Insights
Orech S, Mine MR, Okello F, Nabachenje P, Nankafu B, Uside KA, Lubaale YM.   +6 more
europepmc   +1 more source