Results 41 to 50 of about 952,055 (312)

Sleep-Related Problems and Associations with Occupational Factors among Home Care Personnel

Nordic Journal of Working Life Studies, 2021
Recent demographic developments in Europe have increased the demand for home care. Working in other people’s home environment is challenging. Home care personnel’s musculoskeletal disorders are common, and care personnel overall often have sleep ...
Maria Lindholm, Ingela Målqvist, Magnus Alderling, Lena Hillert, Carl M Lind, Arto Reiman, Mikael Forsman   +6 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of enhanced home care support clinics regarding emergency home visits, hospitalization, and end-of-life care: a retrospective cohort study in a city of Japan

BMC Health Services Research, 2023
Background To meet the increasing demand for home healthcare in Japan as the population ages, home care support clinics/hospitals (HCSCs) and enhanced HCSCs were introduced in 2006 and 2012, respectively.
Yu Sun, Masao Iwagami, Nobuo Sakata, Tomoko Ito, Ryota Inokuchi, Jun Komiyama, Naoaki Kuroda, Nanako Tamiya   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

How returning home for entrepreneurship affects rural common prosperity

International Review of Economics & Finance
This article attempts to construct a logical framework for the impact of returning home for entrepreneurship on rural common prosperity based on the institutional analysis framework driven by the market, government, and society.
Ming Yang, HuaTao Peng, Shunli Yue
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Spiritual Integration of Migrants: A Lisbon Case Study Within the Common Home Agenda and Polyhedron of Intelligibility Framework

Religions
Migration is a multidimensional process that reshapes identities and communities. This article adopts a polyhedral framework inspired by Pope Francis’s Laudato si’ and Michel Foucault’s concepts of “subjectivation” and the “polyhedron of intelligibility”.
Linda Koncz, Alex Villas Boas, César Candiotto   +2 more
doaj   +1 more source

Which aspects of Child Development are Related to the Home Environment? : A Narrative Review [PDF]

Journal of Rehabilitation Sciences and Research, 2019
Background: The home environment is the first context where children have experience, so in the present review article, important aspects of the child development that are influenced by home environment are analyzed, and common questionnaires were ...
Somaye Kavousipor
doaj