Results 91 to 100 of about 566,463 (292)

Effects of climate extremes on the terrestrial carbon cycle : concepts, processes and potential future impacts [PDF]

, 2015
This article is protected by copyright. All rights reserved. Acknowledgements This work emerged from the CARBO-Extreme project, funded by the European Community’s 7th framework programme under grant agreement (FP7-ENV-2008-1-226701).
Babst, Flurin, Bahn, Michael, Beer, Christian, Buchmann, Nina, Canadell, Josep G, Ciais, Philippe, Cramer, Wolfgang, Frank, David, Frank, Dorothea, Ibrom, Andreas, Mahecha, Miguel D, Miglietta, Franco, Poulter, Ben, Rammig, Anja, Reichstein, Markus, Seneviratne, Sonia I, Smith, Pete, Thonicke, Kirsten, van der Velde, Marijn, Vicca, Sara, Walz, Ariane, Wattenbach, Martin, Zavala, Miguel A, Zscheischler, Jakob   +23 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Discovering History: The History of the Ice House Complex

, 2009
A gift to Gettysburg College in 1990 from George W. Olinger and Mae E. Olinger, life long residents of Gettysburg, zestful supporters of local history, common sense preservationists and quiet humanitarians. Their gift of these historic buildings and land
Amrhein, Elizabeth D.
core  

Induction of PEP Carboxylase and Crassulacean Acid Metabolism by Gibberellic Acid in Mesembryanthemum crystallinum [PDF]

, 2001
The induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum was investigated in response to foliar application of gibberellic acid (GA).
Earnest, Jeannine, Edwards, Gerald E., Guralnick, Lonnie J., Hockema, Brandon, Ku, Maurice S.B., Strand, Darren   +5 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Landscape patterns of carbon fluxes in natural and disturbed ice-wedge-polygon tundra

Arctic, Antarctic, and Alpine Research
The degradation of ice-rich permafrost ecosystems due to climate change and infrastructure development strongly impacts carbon exchange dynamics in tundra landscapes.
Anja Kade, Donald A. Walker, Martha K. Raynolds, Amy L. Breen, Olivia M. Hobgood   +4 more
doaj   +1 more source

Ion accumulation and expression of ion homeostasis-related genes associated with halophilism, NaCl-promoted growth in a halophyte Mesembryanthemum crystallinum L.

Plant Production Science, 2020
A halophyte, the common ice plant (Mesembryanthemum crystallinum L.), shows the maximal growth under salinity, in which almost all crops die. The NaCl-stimulated growth, which is referred to as halophilism, is an important trait for adaptation to ...
Dan Q. Tran, Ayako Konishi, John C. Cushman, Masahiro Morokuma, Masanori Toyota, Sakae Agarie   +5 more
doaj   +1 more source

Circular 102 [PDF]

, 1995
In 1989, a systematic evaluation of woody and herbaceous perennial landscape plants was begun at the University of Alaska Fairbanks Georgeson Botanical Garden (64°51’N, 147°52’W).
Barbour, Edie, Berry, Sally, Holloway, Patricia S., Matheke, Grant E.M., Wagner, Patricia J.   +4 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source