Results 51 to 60 of about 81,347 (209)

Isolation and cloning of manganese peroxidase (mnp) gene from oyster mushroom [PDF]

مجله بیوتکنولوژی کشاورزی, 2015
Different enzymes in oyster mushroom (pleurotus oatreatus), can degradate the lignin compounds from the beginning of mycelium growth up to the end of fruiting period in the environment of compost and straw. Wood, plant residue and most of plant wastes in
Mozhgan Parvandi, Mohammad Farsi, Amin Mir Shamsi, Mohsen Ashrafi   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Identification and Population Estimation of Epiphytic Ice Nucleation Active Bacteria Isolated from Stone Fruit Trees in Khorasan-Razavi Province

Majallah-i ḥifāẓat-i giyāhān, 2016
Introduction: Epiphytic bacteria are common inhabitants of plant leaflet surfaces and can have important influences on the plants on which they live. Accurate estimates of epiphytic bacterial population sizes are needed to detect their roles in several ...
E. Taheri, S. Tarighi, P. Taheri
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Interactions of water, ice nucleators and desiccation in invertebrate cold survival

European Journal of Entomology, 2002
Four case studies are used to examine the relationships of water, ice nucleators and desiccation in the cold survival of invertebrates and the viability of frozen plant material: the freeze intolerant Antarctic springtail Cryptopygus antarcticus (Willem)
William BLOCK
doaj   +1 more source

Palaeoclimate characteristics in interior Siberia of MIS 6–2: first insights from the Batagay permafrost mega-thaw slump in the Yana Highlands [PDF]

Climate of the Past, 2017
Syngenetic permafrost deposits formed extensively on and around the arising Beringian subcontinent during the Late Pleistocene sea level lowstands.
K. Ashastina, K. Ashastina, L. Schirrmeister, M. Fuchs, F. Kienast   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Morus alba Fruitless Cultivars: White Mulberry

EDIS, 2014
This group of mulberries is fruitless, a definite plus when compared to the mess created by the abundant fruits of the common White Mulberry. The plant quickly forms a dark green mass of foliage from a short trunk, or group of trunks.
Edward Gilman, Dennis Watson
doaj   +2 more sources