Results 91 to 100 of about 3,195 (236)

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

A High-Performance PWM Algorithm for Common-Mode Voltage Reduction in Three-Phase Voltage Source Inverters [PDF]

, 2011
A high-performance pulsewidth modulation (PWM) algorithm with reduced common-mode voltage (CMV) and satisfactory overall performance is proposed for three-phase PWM inverter drives.
Un, Emre, Emre Ün, Ahmet M. Hava, Hava, Ahmet Masum   +3 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

A Reduced Common-Mode Voltage Control Scheme for Three-Level H10 Converter Considering Dead-Time Effect [PDF]

Common-mode voltage (CMV) has several negative effects on photovoltaic (PV) grid-connected systems and motor drives. To reduce CMV, converter topology improvement draws great interest, such as the novel three-level H8 converter topology.
Guerrero, Josep M.; id_orcid, Hu, Chengkun, Zang, Xian, Rodriguez, Jose, Long, Bo, Chen, Zhihao   +5 more
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Common‐Mode Voltage Analysis and Reduction Method for SiC‐Based Four‐Level Hybrid Clampled Converter

IET Power Electronics
The hybrid clamped converter (HCC) is a novel high‐performance four‐level multilevel converter for medium‐voltage motor drives. However, the high common mode voltage (CMV) in motor drives will cause harmful shaft voltages and bearing currents, which ...
Sheng Yan, Jianyu Pan, Xiaojie Fu, Junwei Xiao, Haibo Tang   +4 more
doaj   +1 more source

An Improved Multiobjective Model-Predictive Control Method for Active Neutral-Point-Clamped Five-Level Converter

IEEE Open Journal of the Industrial Electronics Society
The active neutral-point-clamped five-level converter has drawn much attention in industrial applications. However, common-mode voltage (CMV) suppression, accurate track current, fixed switching frequencies, neutral-point (NP) voltage balance, and flying
Qiguang Ren, Chang Liu, Xiangyang Xing, Rui Zhang, Chenghui Zhang   +4 more
doaj   +1 more source

Common Mode Voltage Mitigation Strategies Using PWM in Neutral-Point-Clamped Multilevel Inverters [PDF]

, 2015
Over the last several decades, there has been consistent growth in the research and development of multilevel voltage-source inverter-based adjustable speed motor drives (ASDs) as a result of low cost, high reliability power semiconductors.
Somogyi, Chad Alexander
core   +1 more source

Common mode voltage impact on wind turbine main shaft bearing [PDF]

, 2021
Main shaft bearing is a critical component in the wind turbine rotating system. But the bearing voltage, which is generated by the potential differences between the bearing and the main shaft, often causes the downtime of the main shaft bearing.
Carlson, Ola, Zhao, Jian, Xu, Xiangdong
core