Results 51 to 60 of about 3,195 (236)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Multi-objectives Integrated Division-Summation Method for LCL-Type Three-Level Grid-Connected Inverter Considering Low- Frequency Common Mode Voltage [PDF]
The LCL-type three-level grid-connected inverter is extensively employed in photovoltaic (PV) power generation systems, which has multiple individually controlled objectives.
Ren, Yiming +7 more
core +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Investigation of Common Mode Voltage in 5-level Diode Clamped MLI using carrier based SPWM Techniques [PDF]
, 2019 The main aim of this paper is to investigate the Common Mode Voltage (CMV) and Total Harmonic Distortion (THD) infive level Diode Clamped Inverter using Carrier based SPWM techniques.
J.E. Muralidhar (6381578) +1 more
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Advanced Functional Materials, EarlyView.The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett +19 more
wiley +1 more source
IEEE Access, 2023 In this study, a common-mode voltage (CMV) reduction scheme based on carrier-based pulse-width modulation (PWM) is proposed for asymmetric dual three-phase hybrid active neutral-point-clamped (ADTP-HANPC) inverters.
Syed Mohammad Maaz, Dong-Choon Lee
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Spontaneous helical alignment of smooth muscle cells is induced within resistance‐vessel‐sized channels patterned within a hydrogel. The extent of the cells’ orientation angle is dependent on the presence and composition of ECM proteins lining the channel wall and cell seeding density.
Victoria D. Vest +5 more
wiley +1 more source
IEEE Access, 2022 In recent years, many pulse width modulation techniques have been explored for three-level impedance-source inverters. Among them, a space vector modulation (SVM) technique using upper/lower shoot-through (UST/LST) insertion provides high voltage gain ...
Vinh-Thanh Tran +3 more
doaj +1 more source
Common-Mode Voltage in Three-Level T-Type Inverter: Modeling, Analysis, and Compensation [PDF]
This paper investigates the origins of common-mode voltage (CMV) noises in SiC MOSFET-based three-level T-type inverters (3LT2I), targeting adjustable speed drive (ASD) systems, and proposes methods for their mitigation.
Griepentrog, Gerd +3 more
core +1 more source