Results 71 to 80 of about 9,617,257 (286)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Nasal Alar Subunit Reconstruction: A Review of Data

Laryngoscope Investigative Otolaryngology
Objectives Alar reconstruction is common, yet high‐quality outcomes data are limited. This review synthesizes the available literature to guide evidence‐informed reconstructive choices. Methods A systematic review identified 35 eligible studies reporting
Deanna C. Menapace, William W. Shockley, Matthew Miller, J. Madison Clark   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Policy implementers’ perspectives of the implementation of the national guidelines for patient safety incident reporting in selected South African public hospitals

BMC Health Services Research
Background The voices of implementers are crucial in enhancing policy implementation. In the North West Province of South Africa, there have been no studies on the implementation of national guidelines for patient safety incident reporting since its ...
Sibongile Dlaba, Nicholin Scheepers, Aaron Asibi Abuosi, Immaculate Sabelile Tenza   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Report on ADRISEISMIC common normative and regulative advanced standards for seismic vulnerability reduction (DT1.2.1)

, 2022
This deliverable (DT1.2.1) presents the selection process and the contents of the best of the collected documents. At first, the methodology of highlighting the Good Practices (GPs) has been developed. It is based on the results of 2nd stage surveys, which were prepared within project activity T.1.1 for each of the collected documents.
Triller, Petra, Kreslin, Maja, Marzani, Giulia, Santangelo, Angela, Charalampos, Fassoulas   +4 more
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Experimental study of implications of SFAS 131: The effects of the new standard on the informativeness of segment reporting [PDF]

This paper analyzes whether the new business segment reporting disclosure rules, SFAS 131, will actually provide capital market participants with more predictive ability than the previous rules. For this we conduct three experiments. Two experiments with
Bar-Yosef, Sasson, Venezia, Itzhak
core  

Checklist for the preparation and review of pain clinical trial publications: a pain-specific supplement to CONSORT

PAIN Reports, 2019
. Introduction:. Randomized clinical trials (RCTs) are considered the gold standard when assessing the efficacy of interventions because randomization of treatment assignment minimizes bias in treatment effect estimates.
Jennifer S. Gewandter, James C. Eisenach, Robert A. Gross, Mark P. Jensen, Francis J. Keefe, David A. Lee, Dennis C. Turk   +6 more
doaj   +1 more source