Results 201 to 210 of about 3,265,734 (307)

Enterprise creation & anti-commons in developing economies: evidence from World Bank doing business data

: This paper looks at the tragedy of anti-commons and its implications on enterprise creation in developing economies. The most important features of the anti-commons are captured under a simplified theoretical economic model. The empirical part uses the
Malki, Karim, Driouchi, Ahmed
core  

Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating. [PDF]

Acta Pharmacol Sin
Dong YP, Wu Y, Zhao YL, Chen YM, Liu TY, Zhang YH, Xie JY, Zhang JF, Zhang H, Chen H, Peng Y, Zhang CL, Rau AR, Hansen KB, Xu HB, Yi F.   +15 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Transformations in Diabetes Care: Lessons From Commons-Based, Peer-Produced Citizen Science. [PDF]

Sociol Health Illn
O'Donnell S, Quigley M.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Mapping cross-domain drivers of Alzheimer's disease risk through integrated network analysis. [PDF]

Alzheimers Dement
Cary GA, Keegan S, Wiley JC, Gockley J, Butler RR, Longo FM, Levey AI, Greenwood AK, Leal K, Carter GW, Emory‐Sage‐SGC‐JAX TREAT‐AD Center.   +10 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Erratum zu: Digitale Gesundheitsanwendungen bei Borderline-Persönlichkeitsstörung. [PDF]

Nervenarzt
Jacob G, Fassbinder E, Klein JP.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Correction: Causal Networks to Inform Decisions for Ecological Restoration. [PDF]

Environ Manage
Kotalik CJ, Rowland FE, Marcot BG, Skrabis KE, Walters DM, Hinck JE, Clements WH, Richer EE, Isanhart JP.   +8 more
europepmc   +1 more source