Results 31 to 40 of about 6,040,073 (242)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Institutionalising data solidarity? The making of expertise in the EU Social Economy Code of Conduct for data sharing

Internet Policy Review
Data sharing has become a cornerstone of EU digital policy. Beyond legislation, informal regulatory arrangements like codes of conduct are used to guide practices across sectors.
Dwayne Ansah, Mai Ishikawa Sutton, Sophie Bloemen, Bonno Pel   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Systematic review and meta-analysis of ex-post evaluations on the effectiveness of carbon pricing

Nature Communications
Today, more than 70 carbon pricing schemes have been implemented around the globe, but their contributions to emissions reductions remains a subject of heated debate in science and policy.
Niklas Döbbeling-Hildebrandt, Klaas Miersch, Tarun M. Khanna, Marion Bachelet, Stephan B. Bruns, Max Callaghan, Ottmar Edenhofer, Christian Flachsland, Piers M. Forster, Matthias Kalkuhl, Nicolas Koch, William F. Lamb, Nils Ohlendorf, Jan Christoph Steckel, Jan C. Minx   +14 more
doaj   +1 more source

Information commons planning: Strategic and operational considerations [PDF]

, 2010
This session will introduce you to planning issues and operational elements that you will need to consider when implementing an Information Commons. The planning process, service models, collaboration issues and relationship building will be discussed ...
Hester, Mountifield
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Machine learning map of climate policy literature reveals disparities between scientific attention, policy density, and emissions

npj Climate Action
Current climate mitigation policies are not sufficient to meet the Paris temperature target, and ramping up efforts will require rapid learning from the scientific literature on climate policies.
Max Callaghan, Lucy Banisch, Niklas Doebbeling-Hildebrandt, Duncan Edmondson, Christian Flachsland, William F. Lamb, Sebastian Levi, Finn Müller-Hansen, Eduardo Posada, Shraddha Vasudevan, Jan C. Minx   +10 more
doaj   +1 more source

Statistical stopping criteria for automated screening in systematic reviews

Systematic Reviews, 2020
Active learning for systematic review screening promises to reduce the human effort required to identify relevant documents for a systematic review. Machines and humans work together, with humans providing training data, and the machine optimising the ...
Max W Callaghan, Finn Müller-Hansen
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source