Results 131 to 140 of about 10,010,540 (385)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Projections of non-communicable disease and health care costs among HIV-positive persons in Italy and the U.S.A.: A modelling study

PLoS ONE, 2017
Background Country-specific forecasts of the growing non-communicable disease (NCD) burden in ageing HIV-positive patients will be key to guide future HIV policies. We provided the first national forecasts for Italy and the Unites States of America (USA)
Mikaela Smit, R. Cassidy, A. Cozzi-Lepri, E. Quiros-Roldan, E. Girardi, A. Mammone, A. Antinori, A. Saracino, F. Bai, S. Rusconi, G. Magnani, F. Castelli, P. Hsue, A. d’Arminio Monforte, T. Hallett   +14 more
semanticscholar   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Communicable Disease Quarterly Report 3rd Qtr 2017 [PDF]

, 2017
Communicable disease counts from 1930 to ...

core  

Implementing a public web based GIS service for feedback of surveillance data on communicable diseases in Sweden [PDF]

, 2004
P Rolfhamre, Katarzyna Grabowska, Karl Ekdahl   +2 more
openalex   +1 more source

Modelling the impact of different front-of-package nutrition labels on mortality from non-communicable chronic disease

International Journal of Behavioral Nutrition and Physical Activity, 2019
BackgroundFront-of-Package nutrition labels (FoPLs) are intended to help reduce the incidence of nutrition-related non-communicable diseases through an improvement in diet quality. FoPLs have been shown to improve the nutritional quality of purchases and
Manon Egnell, Paolo Crosetto, T. d’Almeida, E. Kesse‐Guyot, M. Touvier, B. Ruffieux, S. Hercberg, L. Muller, C. Julia   +8 more
semanticscholar   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Evaluation of Communicable Diseases Surveillance System Structure in Mosul City

, 2023
Yasir Younus, Mohammed Khalifa
openalex   +2 more sources

Non-communicable disease prevention policy process in five African countries authors

BMC Public Health, 2018
BackgroundThe increasing burden of non-communicable diseases (NCDs) in sub-Saharan Africa is causing further burden to the health care systems that are least equipped to deal with the challenge. Countries are developing policies to address major NCD risk
Pamela A. Juma, S. Mohamed, Beatrice L. Matanje Mwagomba, C. Ndinda, Clarisse Mapa-Tassou, M. Oluwasanu, O. Oladepo, O. Abiona, M. Nkhata, J. Wisdom, J. Mbanya   +10 more
semanticscholar   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source