Results 61 to 70 of about 10,010,540 (385)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Medical education and the pursuit of excellence : the quest for the Holy Grail? [PDF]

, 2008
Medical education in Europe is currently facing enormous challenges brought about by the number and the diversity of medical schools that are now within the fold.
Vassallo, Josanne
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Genomic epidemiology of Mycobacterium tuberculosis in Wales

Scientific Reports
Identification of factors contributing to tuberculosis (TB) transmission can guide targeted measures to reduce morbidity. Varying findings for factors associated with TB genomic clustering exist.
Nicole Pacchiarini, Felicity Simkin, Mark Postans, George Ahern, Jiao Song, Clare Brown, Josie Smith, Catie Williams, Matthijs Backx, Daniel Thomas, Thomas R. Connor, Christopher Williams   +11 more
doaj   +1 more source

Performance comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus in detecting Mycobacterium tuberculosis infection among HIV patients in China [PDF]

PeerJ
Introduction No direct comparative study assessing QuantiFERON-TB Gold In-Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for Mycobacterium tuberculosis infection among persons living with HIV (PLHIV) in China has been conducted.
Peng Lu, Haitao Yang, Fang Ge, Kai Wu, Yilin Lian, Xiaoyan Ding, Jingjing Pan, Hui Ding, Wei Lu, Qiao Liu, Limei Zhu   +10 more
doaj   +2 more sources

Social determinants of health inequalities [PDF]

, 2005
The gross inequalities in health that we see within and between countries present a challenge to the world. That there should be a spread of life expectancy of 48 years among countries and 20 years or more within countries is not inevitable. A burgeoning
Marmot, M
core   +1 more source

Communicable Disease Surveillance Ethics in the Age of Big Data and New Technology

Asian Bioethics Review, 2019
Surveillance is essential for communicable disease prevention and control. Traditional notification of demographic and clinical information, about individuals with selected (notifiable) infectious diseases, allows appropriate public health action and is ...
G. Gilbert, C. Degeling, Jane Johnson
semanticscholar   +1 more source

The burden of non-communicable diseases attributable to high BMI in Brazil, 1990–2017: findings from the Global Burden of Disease Study

Population Health Metrics, 2020
Background The prevalence and burden of disease resulting from obesity have increased worldwide. In Brazil, more than half of the population is now overweight. However, the impact of this growing risk factor on disease burden remains inexact.
M. Felisbino-Mendes, Ewerton Cousin, D. Malta, Í. Machado, A. Ribeiro, B. Duncan, M. Schmidt, D. Silva, Scott Glenn, A. Afshin, G. Velásquez-Melendez   +10 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Have purpose‐built vaccine refrigerators reduced the cost of vaccine losses in South Australia?

Australian and New Zealand Journal of Public Health, 2012
Objectives: There is limited epidemiological data on the performance of different refrigerator types for vaccine storage in the real world. This study aims to measure if the introduction of purpose‐built vaccine refrigerators has reduced the cost of ...
Katina D'Onise, Sara Almond, Breda MacDonald, Maureen Watson, Sophie Scrimgeour   +4 more
doaj   +1 more source