Results 61 to 70 of about 9,465,192 (340)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Communicable Diseases and the Workplace [PDF]

, 2019
[Excerpt] Coming to work when we are sick raises some interesting questions: How contagious are we? Should we stay home? What could be done to prevent disease transmission to others, with its effects on absenteeism, performance, and efficiency, as well ...
Brown, Nellie J
core   +1 more source

National mortality burden due to communicable, non-communicable, and other diseases in Ethiopia, 1990–2015: findings from the Global Burden of Disease Study 2015 [PDF]

, 2017
Background: Ethiopia lacks a complete vital registration system that would assist in measuring disease burden and risk factors. We used the Global Burden of Diseases, Injuries, and Risk factors 2015 (GBD 2015) estimates to describe the mortality burden ...
A Misganaw, A Misganaw, Amare Deribew, AR Omran, Awoke Misganaw, Azmeraw T. Amare, B Weldearegawi, Biruck Desalegn Yirsaw, Central Statistical Agency (CSA) [Ethiopia] and ICF, CJL Murray, D Chandramohan, D Hailemariam, D Shamebo, D Shamebo, F Tesfaye, F Tesfaye, Federal Ministry of Health, Ethiopia, GA Biks, GBD 2013 Mortality and Causes of Death Collaborators, Gizachew Assefa Tessema, H Wang, Jed Blore, K Lulu, Kebede Deribe, Kristopher J. Krohn, L Chaker, M Naghavi, Mesoud Mohammed, MH Forouzanfar, Mohsen Naghavi, Molla Gedefaw, Muluken Dessalegn, NJ Kassebaum, P Byass, S Accorsi, S Kuruvilla, Semaw Ferede Abera, Solomon Abrha Damtew, T Araya, Tilahun N. Haregu, Tolesa Bekele, Tom Achoki, W Deressa, Yibeltal Assefa, Yihunie Lakew, Yohannes Adama Melaku   +45 more
core   +2 more sources

Communicable Disease Surveillance Ethics in the Age of Big Data and New Technology

Asian Bioethics Review, 2019
Surveillance is essential for communicable disease prevention and control. Traditional notification of demographic and clinical information, about individuals with selected (notifiable) infectious diseases, allows appropriate public health action and is ...
G. Gilbert, C. Degeling, Jane Johnson
semanticscholar   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Morbidity Pattern Among Out-Patients Attending Urban Health Training Centre in Srinagar [PDF]

, 2018
The current study was designed to identify the morbidity pattern of out-patients attending Urban Health Training Centre in an urban area of a medical college in Srinagar, Pauri Garhwal district, Uttarakhand, North India.
Ali, H. (Haroon), Kumar, S. (Santosh), Raj, A. (Abhishek), Singh, A. K. (Amit)   +3 more
core   +2 more sources

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Use of m-Health Technology for Preventive Interventions to Tackle Cardiometabolic Conditions and Other Non-Communicable Diseases in Latin America- Challenges and Opportunities [PDF]

, 2016
In Latin America, cardiovascular disease (CVD) mortality rates will increase by an estimated 145% from 1990 to 2020. Several challenges related to social strains, inadequate public health infrastructure, and underfinanced healthcare systems make ...
Beratarrechea, Andrea Gabriela, Diez Canseco, Francisco, Irazola, Vilma, Miranda, Jaime, Ramirez Zea, Manuel, Rubinstein, Adolfo Luis   +5 more
core   +1 more source

Reframing non-communicable diseases [PDF]

The Lancet Global Health, 2017
​Proposer de travailler sur les maladies chroniques non-infectieuses comme "maladies socialement transmises" ("socially transmitted conditions") prolonge un lieu commun partage depuis plusieurs decennies en epidemiologie sur le caractere plurifactoriel de ces maladies. Cela ne doit pas empecher de penser que les maladies infectieuses doivent aussi etre
Cavalin, Catherine, Lescoat, Alain
openaire   +6 more sources

First Africa non-communicable disease research conference 2017: sharing evidence and identifying research priorities

Journal of Global Health, 2019
Non-communicable diseases (NCDs) prevalence is rising fastest in lower income settings, and with more devastating outcomes compared to High Income Countries (HICs).
Kenneth Juma, Pamela A. Juma, S. Mohamed, J. Owuor, Agnes N Wanyoike, David Mulabi, George Odinya, Maureen Njeru, G. Yonga   +8 more
semanticscholar   +1 more source