Results 91 to 100 of about 194,149 (294)

Emerging trends in non-communicable disease mortality in South Africa, 1997 - 2010

South African Medical Journal, 2016
National trends in age-standardised death rates (ASDRs) for non-communicable diseases (NCDs) in South Africa (SA) were identified between 1997 and 2010.As part of the second National Burden of Disease Study, vital registration data were used after validity checks, proportional redistribution of missing age, sex and population group, demographic ...
Nojilana, B, Bradshaw, D, Pillay-van Wyk, V, Msemburi, W, Laubscher, R, Somdyala, N I M, Joubert, J D, Groenewald, P, Dorrington, R E   +8 more
openaire   +5 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Nutrition transition in South Asia: the emergence of non-communicable chronic diseases [PDF]

F1000Research, 2015
Overview: South Asian countries have experienced a remarkable economic growth during last two decades along with subsequent transformation in social, economic and food systems. Rising disposable income levels continue to drive the nutrition transition characterized by a shift from a traditional high-carbohydrate, low-fat diets towards diets with a ...
openaire   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A case of human survival of rabies, South Africa

Southern African Journal of Infectious Diseases, 2016
Human survival from rabies is exceptionally rare. We report a case of human survival (with severe neurological sequelae) in a child from South Africa.
Jacqueline Weyer, Veerle Msimang-Dermaux, Janusz T. Paweska, Kevin le Roux, Premi Govender, Jessica Coertse, Wanda Markotter, Louis H. Nel, Lucille H. Blumberg   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The practitioners guide for dealing with the novel Influenza A, H1n1 pandemic

South African Family Practice, 2009
Within three months of its discovery, the new Influenza A (H1n1) swineflu strain has spread to such an extent that a pandemic has been declared by the World Health Organization (WHO). Although most cases seem to be mild, cases of severe disease have also
Marietjie Venter, L. Bloomberg
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Gap Analysis of Environmental Health Research in Malawi : Report to the National Commission of Science and Technology [PDF]

, 2010
The aim of this consultancy was to assess the current gaps in research for the environmental health sector in Malawi, and to recommend research priorities and an effective action plan to address these ...
Lungu, Kingsley, Morse, Tracy, Taulo, Steven   +2 more
core  

A One Health Evaluation of the Southern African Centre for Infectious Disease Surveillance [PDF]

, 2018
Rooted in the recognition that emerging infectious diseases occur at the interface of human, animal, and ecosystem health, the Southern African Centre for Infectious Disease Surveillance (SACIDS) initiative aims to promote a trans-sectoral approach to ...
Anderson, Aragrande, Argyris, Chomel, Coker, Epstein, Gibbs, Giesecke, Hadorn Hirsch, Houe, Jones, Karimuribo, Ledford, Lopez, Lélé, Marjanovic, Marmot, Molyneux, Morens, Nancarrow, Piwowar, Redding, Rock, Rweyemamu, Rweyemamu, Rüegg, Rüegg, Schneider, Scott, Strang, Wolfe, Zinsstag   +31 more
core   +4 more sources