Results 201 to 210 of about 17,047 (255)

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings   +6 more
wiley   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan   +13 more
wiley   +1 more source

Capability, opportunity and motivation for shared decision‐making about valproate as an antiseizure medication treatment for epilepsy in women with pregnancy potential: A qualitative study of patient perspectives

open access: yesBritish Journal of Health Psychology, Volume 31, Issue 1, February 2026.
Abstract Objectives Valproate is a highly effective antiseizure medication but carries significant teratogenic and neurodevelopmental risks to offspring if used during pregnancy. A shared decision‐making (SDM) approach is recommended to guide clinician/patient discussions on valproate suitability for women with pregnancy potential.
Sarah Louise Griffiths   +8 more
wiley   +1 more source

From beginning to end: the synecology of tree‐killing bark beetles, fungi, and trees

open access: yesBiological Reviews, Volume 101, Issue 1, Page 314-335, February 2026.
ABSTRACT Over a century of research has revealed an amazing complexity of behaviours and physiological adaptations that allow tiny bark beetles to overcome large trees, sometimes resulting in outbreaks that kill millions of trees. Turning a tree into a home and successfully raising offspring involves constant interactions among the beetles, the tree ...
Diana L. Six   +3 more
wiley   +1 more source

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