Results 31 to 40 of about 17,047 (255)

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Galileo and EGNOS as an asset for UTM safety and security [PDF]

, 2019
GAUSS (Galileo-EGNOS as an Asset for UTM Safety and Security) is a H2020 project1 that aims at designing and developing high performance positioning systems for drones within the U-Space framework focusing on UAS (Unmanned Aircraft System) VLL (Very Low ...
Andrade-Cetto, Juan, Capitan, Carlos, Dontas, Ioannis, Jia, Huamin, Jimenez, Adrian, Kostaridis, Antonis, Oliveres, Enric, Tesfai, Ivan   +7 more
core  

Compromise-resilient anti-jamming communication in wireless sensor networks [PDF]

Wireless Networks, 2011
Jamming is a kind of Denial-of-Service attack in which an adversary purposefully emits radio frequency signals to corrupt the wireless transmissions among normal nodes. Although some research has been conducted on countering jamming attacks, few works consider jamming attacks launched by insiders, where an attacker first compromises some legitimate ...
Xuan Jiang, Wenhui Hu, Sencun Zhu, Guohong Cao   +3 more
openaire   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Cyber-Security in Smart Grid: Survey and Challenges

, 2018
Smart grid uses the power of information technology to intelligently deliver energy to customers by using a two-way communication, and wisely meet the environmental requirements by facilitating the integration of green technologies.
Ghazi, Hamid El, Ghazi, Hassan El, Kaabouch, Naima, Mrabet, Zakaria El   +3 more
core   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

Intelligent OFDM telecommunication system. Part 3. Anti-eavesdropping and anti-jamming properties of system, based on many-parameter wavelet and Golay transforms [PDF]

, 2019
In this paper, we aim to investigate the superiority and practicability of many-parameter Fourier transforms (MPFT) from the physical layer security (PHY-LS) perspective.
Chasovskikh, V. P., Komarov, D. E., Labunets, V. G., Ostheimer, E. V., Smetanin, J. G.   +4 more
core  

Parental choice of private tuition: Valuing attention, judging quality and navigating access in England's underregulated supplementary education market

British Educational Research Journal, EarlyView.
Abstract Private supplementary education is burgeoning worldwide, and over 25% of English children have received private tutoring. The neoliberalisation of education and parents' responsibilisation for children's attainment have driven market growth, but not all can afford to participate.
Sarah L. Holloway, Sam Whewall, Helena Pimlott‐Wilson   +2 more
wiley   +1 more source