Results 61 to 70 of about 163,615 (303)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Phonetics Learning Anxiety – Results of a Preliminary Study [PDF]

, 2013
The Phonetics Learning Anxiety Scale, a 44-item questionnaire based on a 6-point Likert scale, designed for the purpose of the research sheds light on the nature of this peculiar type of apprehension experienced by advanced FL learners in a specific ...
Argamon, Argamon, Ashcraft, Ashcraft, Bailey, Bailey, Baran, Baran, Baran, Baran, Broadbent, Broadbent, Celce, Celce, Cheng, Cheng, Darwin, Darwin, Eysenck, Eysenck, Eysenck, Eysenck, Friedman, Friedman, Gardner, Gardner, Gregersen, Gregersen, Hilleson, Hilleson, Horwitz, Horwitz, Horwitz, Horwitz, Horwitz, Horwitz, Horwitz, Horwitz, Kennerly, Kennerly, Kim, Kim, Krashen, Krashen, Lesse, Lesse, Lewis, Lewis, MacIntyre, MacIntyre, MacIntyre, MacIntyre, Mathews, Mathews, Mathews, Mathews, Małgorzata Baran-Łucarz, Onwuegbuzie, Onwuegbuzie, Pekrun, Pekrun, Phillips, Phillips, Piechurska, Piechurska, Rathus, Rathus, Riskind, Riskind, Ruiz, Ruiz, Saito, Saito, Saito, Saito, Scovel, Scovel, Sobkowiak, Sobkowiak, Spielman, Spielman, VanPatten, VanPatten, Vasa, Vasa, Vogely, Vogely, Wade, Wade, Watson, Watson, Woodrow, Woodrow   +92 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Challenging academic presentations [PDF]

, 2015
Academic presentations are hard to teach and students frequently have difficulties in their preparation and delivery. This article aims to present some of the findings of researchers in this area related to communication apprehension encountered both by ...
Hadjikoteva, Milka
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A theoretical integration of the social skill deficit vulnerability model and social determination theory to examine young adult loneliness

Frontiers in Communication
Loneliness is an urgent public health crisis that is associated with deleterious outcomes such as early mortality and mental health issues. This study investigates how interpersonal communication apprehension is linked to loneliness through the basic ...
Timothy Curran, Rebecca E. Elwood
doaj   +1 more source

Investigating the Communication Apprehension Model of Physicians in Public Hospitals of Yazd City

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2023
Background: A good and healthy communication between the physician and patient and the therapeutic staff is the basis of good medical care, and communication skills play an important role in patient's satisfaction and their treatment.
Rohollah Mirjalili, Hossein Kazemi, Malike Beheshti Far   +2 more
doaj  

Foreign language anxiety and self-perceived English pronunciation competence

Studies in Second Language Learning and Teaching, 2011
In foreign language learning a negative correlation has been reported be-tween language anxiety and both oral performance (Liu, 2006; Stephenson Wilson, 2006; Woodrow 2006) and self-perceived levels of speaking ability (Kitano, 2001; MacIntyre, Noels ...
Magdalena Szyszka
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

First-year students’ communication apprehension in learning French as foreign language

Indonesian Journal of Applied Linguistics, 2020
Learning a foreign language and being first-year students at the same time can be challenging as they struggle to make the transition in learning a new language and adjusting to their new lives as a university student. Students have to deal with not only
Dante Darmawangsa, Vidi Sukmayadi, Azizul Halim Yahya   +2 more
doaj   +1 more source