Results 121 to 130 of about 5,642,848 (291)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Identifying and Ranking of Best Influential Spreaders With Extended Clustering Coefficient Local Global Centrality Method

IEEE Access
The detection and ranking of influential nodes in complex networks are crucial for various practical applications such as identifying potential drug targets in protein-to-protein interaction networks, critical devices in communication networks, key ...
Mondikathi Chiranjeevi, V Sateeshkrishna Dhuli, Murali Krishna Enduri, Linga Reddy Cenkeramaddi   +3 more
doaj   +1 more source

Quantum Communication Complexity

, 2000
11 pages, LaTeX, to appear in: Workshop Proceedings of the 27th International Colloquium on Automata, Languages and Programming 2000, Workshop on Boolean Functions and ...
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A hierarchy of constant communication complexity

Information and Computation
Similarly to the Chomsky hierarchy, we offer a classification of communication complexity measures such that these measures are organized into equivalence classes. Different from previous attempts of this endeavor, we consider two communication complexity measures as equivalent, if, when one is constant, then the other is constant as well, and vice ...
Andris Ambainis, Hartmut Klauck, Debbie Lim   +2 more
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Quantifying Node Influence in Networks: Isolating-Betweenness Centrality for Improved Ranking

IEEE Access
In complex networks, node impact refers to an individual node’s significance or influence within the structure. The evaluation of the impact of the nodes in information transmission, prevention of pandemics, and resilience applications of the ...
Mondikathi Chiranjeevi, V. Sateeshkrishna Dhuli, Murali Krishna Enduri, Koduru Hajarathaiah, Linga Reddy Cenkeramaddi   +4 more
doaj   +1 more source