Results 31 to 40 of about 476,268 (262)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Individual Noise-Tolerance Profiles and Neural Signal-to-Noise Ratio: Insights into Predicting Speech-in-Noise Performance and Noise-Reduction Outcomes

Audiology Research
Background/Objectives: Individuals with similar hearing sensitivity exhibit varying levels of tolerance to background noise, a trait tied to unique individual characteristics that affect their responsiveness to noise reduction (NR) processing in hearing ...
Subong Kim, Susan Arzac, Natalie Dokic, Jenn Donnelly, Nicole Genser, Kristen Nortwich, Alexis Rooney   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The Social Validity of Telepractice among Spanish-Speaking Caregivers of English Learners: An Examination of Moderators

International Journal of Telerehabilitation, 2017
The purpose of the present paper was to examine the social validity of telepractice as a service delivery model for Spanish-speaking families of English learners.
Lisa Fitton, Kristina N. Bustamante, Carla Wood   +2 more
doaj   +1 more source

Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition

Scientific Reports, 2023
Feedback networks in the brain regulate downstream auditory function as peripheral as the cochlea. However, the upstream neural consequences of this peripheral regulation are less understood.
Sriram Boothalingam, Abigayle Peterson, Lindsey Powell, Vijayalakshmi Easwar   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Lived Experience of Being a Speech-Language Therapist in the Western Cape Public Health Service

South African Journal of Communication Disorders, 2008
This study explores the lived experience of being a Speech-Language Therapist (S-L Therapist) in the South African Western Cape public health service. The lived experience of seven S-L Therapists with varied clinical experience was illuminated using a ...
Jocelyn A. Warden, Patricia Mayers, Harsha Kathard   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Stable, flexible, common, and distinct behaviors support rule-based and information-integration category learning

npj Science of Learning, 2023
The ability to organize variable sensory signals into discrete categories is a fundamental process in human cognition thought to underlie many real-world learning problems.
Casey L. Roark, Bharath Chandrasekaran
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source