Results 51 to 60 of about 1,583,273 (333)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Design and Analysis of Field Telemedicine Information Communication Protocol Based on Wireless Sensor Network

IEEE Access, 2019
In order to solve the problem of safe transmission of telemedicine information in complex field environment, a new communication protocol of wireless sensor network (WSN) is designed in this paper.
Gang Guo, Gengxin Sun, Sheng Bin, Fengjing Shao   +3 more
doaj   +1 more source

Quantum private queries

, 2007
We propose a cheat sensitive quantum protocol to perform a private search on a classical database which is efficient in terms of communication complexity.
A. Ambainis, A. S. Holevo, C. Cachin, C. Gentry, C. H. Bennett, E. Kushilevitz, Lorenzo Maccone, M. A. Nielsen, S. Wiesner, Seth Lloyd, Vittorio Giovannetti   +10 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Design of multi-bus monitoring system of testbed of shearer gearbox

Gong-kuang zidonghua, 2014
According to distribution and requirement of data transmission of testbed of shearer gearbox, a multi-bus monitoring system of testbed of shearer gearbox was designed, topology and communication realization of the system were introduced in details.
WU Zhouxin, CHEN Jie, HONG Rongjing, XU Wei   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

FedFit: Server Aggregation Through Linear Regression in Federated Learning

IEEE Access
We present a conceptually novel framework for Federated Learning (FL) called FedFit for a flexible solver to address FL problems. The FedFit framework consists of two components: model compression to upload a local model from a client to the server and ...
Taiga Kashima, Ikki Kishida, Ayako Amma, Hideki Nakayama   +3 more
doaj   +1 more source

Testing communication protocols [PDF]

IEEE Software, 1992
The authors describe a unifying, common intermediate model that lets Lotos specifications and TTCN test suites be translated into extended finite-state machines, providing a single medium for conformance testing. The paper covers specifying a protocol in Lotos, specifying test suites in TTCN, translating specifications to CIM, and the generation ...
Naik, K., Sarikaya, B.
openaire   +3 more sources