Results 41 to 50 of about 2,291,416 (288)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Survey of Solving Approaches for Multiple Objective Flexible Job Shop Scheduling Problems

Cybernetics and Information Technologies, 2015
Many real life scheduling problems can be formulated as Flexible Job Shop Scheduling Problems (FJSSPs) which simultaneously optimize several conflicting criteria. A typical feature of such problems is their high computational complexity.
Genova Krasimira, Kirilov Leoneed, Guliashki Vassil   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Ultra-Compact Vertical Fiber-to-Chip Grating Couplers on Silicon-on-Insulator by Inverse Design

IEEE Photonics Journal
Grating couplers that combine true vertical access, compact footprints, and foundry compatibility are vital for scalable photonic integration. However, conventional designs typically rely on reflectors, long tapers, or fiber tilt to achieve efficient ...
Jiahao Li, Xiang Li, Lin Wu, Hongguang Sun, Bohao Sun, Tiancai Jiang, Ming Luo, Zhan Gao, Yunlong Bai, Pengfei Ma, Yinqiu Gui, Jin Tao, Zhaofu Zhang, Hanbing Li, Tianye Huang, Ying Qiu   +15 more
doaj   +1 more source

Density-Based Statistical Clustering: Enabling Sidefire Ultrasonic Traffic Sensing in Smart Cities

Journal of Advanced Transportation, 2018
Traffic routing is a central challenge in the context of urban areas, with a direct impact on personal mobility, traffic congestion, and air pollution.
Volker Lücken, Nils Voss, Julien Schreier, Thomas Baag, Michael Gehring, Matthias Raschen, Christian Lanius, Rainer Leupers, Gerd Ascheid   +8 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Autonomic Properties in Traffic Control

Cybernetics and Information Technologies, 2013
The operation of a complex system like a transportation network is considered with respect to the opportunities to identify the application of autonomic properties. The autonomic features of self-properties are analyzed.
Stoilova Krasimira, Stoilov Todor, Nikolov Konstantin   +2 more
doaj   +1 more source

MODELING OF BUSINESS PROCESSES FOR MANAGING INTEGRATIVE DIGITAL DEVELOPMENT OF ENTERPRISES [PDF]

Academy Review
It has been proven that the development of information and communication services enterprises is of strategic importance for the complementary growth of all sectors of the Ukrainian economy and serves as a platform for boosting and advancing proactive ...
Оlena V. Vynogradova, Svitlana V. Lehominova, Aliona Yu. Goloborodko, Tetiana I. Nosova   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source