Results 81 to 90 of about 2,315,851 (299)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

AISR Connections, Fall 2011 (2011-2012 Orientation Issue) [PDF]

, 2011
Yearly publication of AISR Connections for 2011-2012. Issue includes: FACT Program Incorporates iPads Classroom Technologies & Videoconferencing Jefferson Digital Commons Posts Half Million Downloads The mission of Academic & Instructional Support ...
AISR,
core   +1 more source

Practical cryptographic strategies in the post-quantum era

, 2018
We review new frontiers in information security technologies in communications and distributed storage technologies with the use of classical, quantum, hybrid classical-quantum, and post-quantum cryptography.
Fedorov, A. K., Kabanov, I. S., Kurochkin, Y. V., Yunusov, R. R.   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Towards Robust Evaluation of Aesthetic and Photographic Quality Metrics: Insights from a Comprehensive Dataset

Complexity
In recent years, the development of metrics to evaluate image aesthetics and photographic quality has proliferated. However, validating these metrics presents challenges due to the inherently subjective nature of aesthetics and photographic quality ...
Iria Santos, Miguel A. Casal, João Correia, Álvaro Torrente-Patiño, Penousal Machado, Juan Romero   +5 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Information and Communication Technologies and Migration [PDF]

Surveying existing literature, this paper starts by identifying links between attainments in human development and the presence of ICTs. The research then looks at instances where ICTs affect the opportunity for migration and how they affect its outcomes.
Hamel, Jean-Yves
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

An integrated approach to forecasting software system quality using bayesian correction, multi-criteria optimization, and meta-learning

Радіоелектронні і комп'ютерні системи
The aim of this study is to improve modern methods for forecasting the quantitative characteristics of software system quality to enhance reliability, efficiency, and adaptability in dynamic IT environments.
Anton Shantyr, Olha Zinchenko, Kamila Storchak, Viktor Vyshnivskyi, Olga Morozova   +4 more
doaj   +1 more source