Results 21 to 30 of about 2,604,406 (261)

Pengembangan Community Based Tourism sebagai Strategi Pemberdayaan Ekonomi Masyarakat di Kabupaten Kulon Progo, Daerah Istimewa YOGYAKARTA [PDF]

, 2016
Penelitian ini bertujuan untuk: (1) mengetahui upaya yang dilakukan oleh pemerintah Kabupaten Kulon Progo dalam mengembangkan Community Based Tourism (CBT), (2) mengidentifikasi potensi wisata yang dapat dikembangkan menjadi CBT, (3) mendapatkan ...
Dewi, U. (Utami), Fitriana, K. N. (Kurnia), Rahayu, S. (Sugi)   +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Enabling community-based metrology for wood-degrading fungi [PDF]

, 2020
Background: Lignocellulosic biomass could support a greatly-expanded bioeconomy. Current strategies for using biomass typically rely on single-cell organisms and extensive ancillary equipment to produce precursors for downstream manufacturing processes ...
Adamala, Katarzyna P., Clamons, Samuel, Endy, Drew, Gaut, Nathaniel, Kamakaka, Rohinton, Luccioni, Marina, Perez, Rolando, Silver, Pamela A., Stirling, Finn   +8 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Keberhasilan Community Based Tourism di Desa Wisata Kembangarum, Pentingsari dan Nglanggeran [PDF]

, 2014
Daerah Istimewa Yogyakarta adalah Provinsi dengan tingkat kemiskinan tertinggi di Pulau Jawa, namun memiliki potensi pariwisata yang tinggi. Hal ini dikarenakan DIY memiliki faktor yang berkenaan dengan keanekaragaman objek, dan ragam spesifikasi objek ...
Asnawi, A. (Asnawi), Purbasari, N. (Novia)   +1 more
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

community –based consequences, community –based management, community involvement. [PDF]

Geographical Researches Quarterly Journal, 2017
The goal of this article is sociological exploration of community–based management in prosperity of social services to citizens and the consequences of this method of management. Taking community-based management into account is necessary in order to achieve collaboration and social participation opportunities for people.
openaire   +2 more sources

Jails and Community-Based Health Care [PDF]

, 2008
Outlines RWJF's Community-Oriented Correctional Health Services (COCHS) approach to providing medical care to inmates with chronic illnesses -- connecting them with community health centers to be assigned dually based physicians and case ...

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