Results 41 to 50 of about 4,688,967 (207)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Factors Associated with Loneliness among Institutionalized and Community Dwelling Elders [PDF]

Alexandria Scientific Nursing Journal, 2015
Satisfying social relationships are vital for elder's mental and physical health. Deficitsin the quality of these social relationships can lead to feelings of isolation and loneliness inelders.
Nadia Hassan, Tarek Ahmed, Hanaa Ibrahim
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Use of Medicines Among a Brazilian Elderly Sample: A Cross-sectional Study

International Journal of Gerontology, 2011
Background: The use of multiple medicines is very frequent among the elderly, allowing them to perceive more often adverse side effects from drugs and present undesirable drug interactions.
Adriana Mathias Pereira da Silva Marchini, Camila Porto de Deco, Michele Roberta Vieira Silva, Karina Bortolin Lodi, Rosilene Fernandes da Rocha, Leonardo Marchini   +5 more
doaj   +1 more source

Social Determinants of Health in Community-Dwelling Dementia Patients Aged 65 and Over: Analysis of the 2019 National Health Interview Survey

Gerontology and Geriatric Medicine, 2023
Alzheimer’s Disease and related dementias affect 3.4 million community-dwelling adults in the United States. Given the burden of disease, a greater understanding of modifiable risk factors is crucial for targeted public health strategies.
Joanne M. Li, Malaz A. Boustani MD, MPH, Dustin D. French PhD   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Influencing factors of attitudes towards death and demands for death education among community-dwelling Chinese older adults: a cross-sectional study

BMC Public Health, 2022
Background Considering older adults are getting closer to the end-of-life and face death more directly. Attitudes to death not only affect the physical and mental health of older adults, but also affect their acceptance of hospice care, even the quality ...
Lei Lei, Hongyan Zhao, Lijuan Ran, Lihua Wang, Yu Luo   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Polypharmacy and patterns of medication use in the final year of life among people living with dementia in Canada: A case-control study

Journal of International Medical Research
Objective At the end of life, changing healthcare needs may lead to decreased use of preventive therapies and increased use of medications for symptom management.
Jasmine Mah, Catherine Richer, Abby Emdin, Kenneth Rockwood, Samuel Stewart, Melissa K Andrew, Shanna C Trenaman   +6 more
doaj   +1 more source

Vitamin D and Associations with Walking Ability in Community- Dwelling Elderly Adults

, 2017
To access publisher's full text version of this article click on the hyperlink belowEpidemiological studies have suggested a positive association between vitamin D status and physical function.
OG, Geirsdottir, A, Ramel
core   +1 more source