Results 61 to 70 of about 6,079,260 (312)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

MALAMA: Cultivating Food Sovereignty through Backyard Aquaponics with Native Hawaiian Families

open access: yesGenealogy
Native Hawaiians were a healthy and robust population who developed a sophisticated food system that was dismantled by colonization. Currently, Native Hawaiians face pervasive health disparities due to the limited access to healthy foods and lifestyles ...
Jane J. Chung-Do   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Effective community-based services [PDF]

open access: yes
This Policy brief explores what makes community-based services for children and families effective. It identifies interpersonal and structural features that characterise effective services, and shows that how services are delivered is as important as ...
Centre for Community Child Health
core  

A Community-Based Participatory Action Research for Roma Health Justice in a Deprived District in Spain [PDF]

open access: yes, 2019
Addressing health disparities and promoting health equity for Roma has been a challenge. The Roma are the largest disadvantaged ethnic minority population in Europe and have been the victims of deep social and economic injustices, institutional ...
Balcázar, Fabricio   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Physician, Heal Thy Community

open access: yesMarshall Journal of Medicine, 2017
What if the opioid epidemic and the chronic health problems we encounter in West Virginia and beyond are a symptom of a deeper problem? How can we create healthcare to address the root issues here, and then spread these solutions globally?
Clay B. Marsh
doaj   +1 more source

Early years care and education [PDF]

open access: yes
Children learn and develop through a combination of experiences, within and outside the family home. This Policy Brief explores the distinction that is often made about the role of care and education in children’s services and highlights the importance ...
Centre for Community Child Health
core  

Perception of Community Health Workers in Indonesia Toward Patients with Mental Disorders [PDF]

open access: yes, 2016
In Indonesia, there are any community health volunteers called Kader. Although Kaders are members of mental health volunteer, they sometimes show negative attitude to psychotic persons, even they have already got some training about mental health.
Kageyama, T. (Takayuki)   +1 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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