We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang +10 more
wiley +1 more source
Time to Act; Let Us Unite to Eliminate Malaria Among Pregnant Women in War Zone From Eastern Democratic Republic of the Congo: A Review. [PDF]
Akilimali A +13 more
europepmc +1 more source
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang +7 more
wiley +1 more source
Rural Health Transformation: Opportunity for Physical Activity Promotion Through Interprofessional Collaboration. [PDF]
Meyer SM, Srivastava SB.
europepmc +1 more source
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang +16 more
wiley +1 more source
Policy integration of pediatric oral health: aligning medicine and dentistry for child well-being. [PDF]
Mistry LN +5 more
europepmc +1 more source
Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale +6 more
wiley +1 more source
Conquering today's health paradox with the power of HEAL - an expert consensus report plus research priorities and policymaker roadmap. [PDF]
Wirnitzer KC +57 more
europepmc +1 more source
Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu +4 more
wiley +1 more source
Strengthening early rabies education and preventive measures - Reflections on 'empowering adolescents in Lucknow with rabies awareness: An interventional study'. [PDF]
Shivale SJ.
europepmc +1 more source

