Results 51 to 60 of about 16,772,494 (262)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Can smartphones and tablets improve the management of childhood illness in Tanzania? A qualitative study from a primary health care worker’s perspective [PDF]

, 2015
The impact of the Integrated Management of Childhood Illness (IMCI) strategy has been less than anticipated because of poor uptake. Electronic algorithms have the potential to improve quality of health care in children. However, feasibility studies about
Amani Flexson Shao, Clotilde Rambaud-Althaus, Swai, N., Judith Kahama-Maro, D’Acremont, Valerie, Valerie D’Acremont, Constanze Pfeiffer, Pfeiffer, Constanze, D'Acremont, V., Pfeiffer, C., Shao, A.F., Kahama-Maro, J., D'Acremont, Valerie, Blaise Genton, Shao, Amani Flexson, Rambaud-Althaus, Clotilde, Ndeniria Swai, Kahama-Maro, Judith, Rambaud-Althaus, C., Genton, B., Swai, Ndeniria, Genton, Blaise   +21 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Community Health Worker Requirements to Accelerate Progress Towards Universal Health Coverage in Africa: An Overview of Contemporary Estimates and Implications of Full-Time Versus Part-Time Working Arrangements

Inquiry: The Journal of Health Care Organization, Provision, and Financing
Primary health care is the most effective approach to achieving universal health coverage (UHC) and ensuring health security. In this approach, community health workers play a crucial role by delivering a comprehensive array of preventive, promotive, and
James Avoka Asamani PhD, Sunny C. Okoroafor PhD, Kasonde Mwinga MMed   +2 more
doaj   +1 more source

“I cannot say no when a pregnant woman needs my support to get to the health centre”: involvement of community health workers in Rwanda’s maternal health

BMC Health Services Research, 2020
Background In Rwanda, maternal community health workers (M-CHWs) are involved in the country’s overall health system. In maternal health, their role includes the provision of preventive and promotional health services at the community level. They provide
Germaine Tuyisenge, Celestin Hategeka, Isaac Luginaah, David F. Cechetto, Stephen Rulisa   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Feasibility of task-sharing with community health workers for the identification, emergency management and referral of women with pre-eclampsia, in Mozambique

Reproductive Health, 2021
Plain Language Summary Maternal mortality is an important public health problem in Mozambique. Delays in reaching health facilities and insufficient health care professionals call for innovative community-level solutions. We conducted a study to describe
Esperança Sevene, Helena Boene, Marianne Vidler, Anifa Valá, Salésio Macuacua, Orvalho Augusto, Quinhas Fernandes, Cassimo Bique, Eusébio Macete, Mohsin Sidat, Peter von Dadelszen, Khátia Munguambe, CLIP Feasibility Working Group   +12 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Comparing the Job Satisfaction and Intention to Leave of Different Categories of Health Workers in Tanzania, Malawi, and South Africa. [PDF]

, 2013
Job satisfaction is an important determinant of health worker motivation, retention, and performance, all of which are critical to improving the functioning of health systems in low- and middle-income countries.
Normand, Charles, Fresier Maseko, Chirwa, Maureen, Mwisongo, Aziza, Ditlopo, Prudence, Prudence Ditlopo, Duane Blaauw, Maseko, Fresier, Blaauw, Duane, Steve Thomas, Charles Normand, Aziza Mwisongo, Thomas, Steve, Posy Bidwell, Maureen Chirwa, Bidwell, Posy   +15 more
core   +1 more source