Results 51 to 60 of about 4,910,330 (295)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The Therapeutic Effect of a Multistrain Probiotic on Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study

open access: yesGastroenterology Research and Practice, 2018
Backgrounds. Recent studies suggest that diarrhea-predominant irritable bowel syndrome (IBS) is associated with intestinal bacterial microflora, colonic inflammation, and small intestinal bacterial overgrowth (SIBO).
Seok-Hoon Lee   +3 more
doaj   +1 more source

Knowledge, attitude and behaviour of general practitioners in Shanghai during the pandemic of COVID-19: a cross-sectional study

open access: yesBMJ Open, 2022
Objectives To understand the knowledge, attitude and behaviour of general practitioners (GPs) towards COVID-19 and to provide evidence for improved prevention and control measures against the pandemic.Study design A cross-sectional study was conducted ...
Jian Wang   +3 more
doaj   +1 more source

Service-Learning Practice in Upper Division Geoscience Courses: Bridging Undergraduate Learning, Teaching, and Research [PDF]

open access: yes, 2004
This article describes the use of service-learning practice in geoscience courses taught at the University of Connecticut. The stated objectives for instituting this practice are: to foster student interest in earth sciences through community service; to
Anthony Philpotts   +2 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Psychometric properties of the Jefferson Scale of Empathy: a COSMIN systematic review protocol

open access: yesSystematic Reviews, 2019
Background Empathy is an important characteristic to possess for healthcare professionals. It has been found to improve communication between professionals and patients and to improve clinical health outcomes.
Brett Williams, Bronwyn Beovich
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Postgraduate training in general practice in Germany: A narrative review

open access: yesGMS German Medical Science
Postgraduate training varies significantly both between countries and among medical specialties within a nation, due to differences in medical education and health care systems.
Tornow, Caroline   +3 more
doaj   +1 more source

A situational analysis of human resource and non-communicable diseases management for community health workers in Chengdu, China: a cross-sectional study

open access: yesBMC Health Services Research, 2023
Background Non-communicable diseases (NCDs) pose a major challenge to health economic cost and residents’ health status. Community health workers (CHWs) are the gatekeeper of primary health care.
Jinhua Chen   +13 more
doaj   +1 more source

Building Communities of Practice [PDF]

open access: yes, 2008
{Excerpt} According to Etienne Wenger, communities of practice are groups of people who share a passion for something they do and who interact regularly to learn how to do it better.
Serrat, Olivier
core   +1 more source

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