Results 51 to 60 of about 3,014,431 (335)

Dose-response Associations of Physical Activity and Sitting Time With All-cause Mortality in Older Japanese Adults

Journal of Epidemiology
Purpose: Although examining the dose-response curves of physical activity (PA) and sitting time with health-related outcomes is an important research agenda, the results for older Japanese adults are extremely limited.
Satoshi Seino, Takumi Abe, Yu Nofuji, Toshiki Hata, Shoji Shinkai, Akihiko Kitamura, Yoshinori Fujiwara   +6 more
doaj   +1 more source

Association between Hypometabolism in the Supplementary Motor Area and Fear of Falling in Older Adults

Frontiers in Aging Neuroscience, 2017
Background: A better understanding of the neural mechanisms that underlie the development of fear of falling (FoF) in seniors may help to detect potential treatable factors and reduce future falls. We therefore investigate the neural correlates of FoF in
Ryota Sakurai, Ryota Sakurai, Ryota Sakurai, Ryota Sakurai, Yoshinori Fujiwara, Masashi Yasunaga, Hiroyuki Suzuki, Kazuyuki Kanosue, Manuel Montero-Odasso, Kenji Ishii   +9 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

COVID-19 vaccine hesitancy and vaccine passports: a cross-sectional conjoint experiment in Japan

BMJ Open, 2022
Objectives While the development of vaccines against the Novel Coronavirus (COVID-19) brought hope of establishing herd immunity and ending the global pandemic, vaccine hesitancy can hinder the progress towards herd immunity.
Shohei Okamoto, Kazuki Kamimura, Kohei Komamura   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Prevalence of frailty, cognitive impairment, and sarcopenia in outpatients with cardiometabolic disease in a frailty clinic

BMC Geriatrics, 2018
Background Although frailty and cognitive impairment are critical risk factors for disability and mortality in the general population of older inhabitants, the prevalence and incidence of these factors in individuals treated in the specialty outpatient ...
Yoshiaki Tamura, Joji Ishikawa, Yoshinori Fujiwara, Masashi Tanaka, Nobuo Kanazawa, Yuko Chiba, Ai Iizuka, Sho Kaito, Jun Tanaka, Masamitsu Sugie, Takashi Nishimura, Akiko Kanemaru, Keigo Shimoji, Hirohiko Hirano, Ko Furuta, Akihiko Kitamura, Satoshi Seino, Shoji Shinkai, Kazumasa Harada, Shunei Kyo, Hideki Ito, Atsushi Araki   +21 more
doaj   +1 more source

Association between sarcopenia and oral functions in community‐dwelling older adults: A cross‐sectional study

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Few studies have examined the state of oral function in older adults with sarcopenia. We assessed the oral functions of community‐dwelling older adults with sarcopenia from multiple perspectives to clarify their potentially low oral function ...
Yoshihiro Kugimiya, Masanori Iwasaki, Yuki Ohara, Keiko Motokawa, Ayako Edahiro, Maki Shirobe, Yutaka Watanabe, Yu Taniguchi, Satoshi Seino, Takumi Abe, Shuichi Obuchi, Hisashi Kawai, Takeshi Kera, Yoshinori Fujiwara, Akihiko Kitamura, Kazushige Ihara, Hunkyung Kim, Shoji Shinkai, Hirohiko Hirano   +18 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Dynapenic abdominal obesity is associated with mild cognitive impairment in patients with cardiometabolic disease: a cross-sectional study

BMC Geriatrics, 2022
Background Dementia is an important health issue for older people and requires early intervention in the mild cognitive impairment (MCI) stage to manage risk factors.
Kazuhito Oba, Yoshiaki Tamura, Joji Ishikawa, Hiroyuki Suzuki, Yoshinori Fujiwara, Aya Tachibana, Remi Kodera, Kenji Toyoshima, Yuko Chiba, Atsushi Araki   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source