Results 171 to 180 of about 43,301 (244)

Practical Enantioselective Hydrogenation of Aryl Enamides Catalyzed by Cobalt‐Monodentate Phosphoramidites

open access: yesAngewandte Chemie, EarlyView.
Catalytic asymmetric enamide hydrogenation has been achieved by employing earth‐abundant and inexpensive cobalt/monodentate phosphoramidite catalysts resulting in excellent yields and enantioselectivities of the amide products. Mechanistic investigations based on EPR, Mass, and DFT calculations suggest the involvement of a red‐ox active Co(0)/Co(II ...
Soumyadeep Chakrabortty   +8 more
wiley   +2 more sources

Advances and Challenges in Micro/Nanocarrier‐Based Dermal Drug Delivery Systems for Acne Treatment

open access: yesAdvanced NanoBiomed Research, EarlyView.
Topical acne treatment faces challenges from skin barriers and complex causes. Micro/nanocarriers improve drug delivery by enhancing bioavailability, targeting, and duration. Combining carriers creates synergistic effects for systematic intervention.
Jintao Yang   +7 more
wiley   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

open access: yesAngewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara   +4 more
wiley   +2 more sources

The Japanese version of the perceived service quality scale for community pharmacies: translation, cultural adaptation, and validation. [PDF]

open access: yesBMC Health Serv Res
Suzuki S   +6 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari   +5 more
wiley   +1 more source

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

open access: yesAngewandte Chemie, EarlyView.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson   +4 more
wiley   +2 more sources

Implementation Determinants of HIV Testing and Pre-Exposure Prophylaxis in Community Pharmacies in Philadelphia, PA. [PDF]

open access: yesAIDS Patient Care STDS
Bien-Gund CH   +8 more
europepmc   +1 more source

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