Results 211 to 220 of about 74,444 (276)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Corrigendum to "Deaf, deaf-blind and hard of hearing needs and perceptions of community pharmacy services". [PDF]

Can Pharm J (Ott)
europepmc   +1 more source

Community Pharmacy Based Model for HIV Care and Services: Attitudes and Perceptions of Practitioners in Jos, Nigeria

, 2019
Maxwell L. P. Dapar, Joseph Benzakoun, Pandell A. Damun, C. R. Okunlola, E. Ahmadu, B Aya, P. N. Alphonsus   +6 more
openalex   +2 more sources

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Continuities in Policies and Turnover Among Actors: Instrument Constituencies in French Primary Care Reforms

European Policy Analysis, EarlyView.
ABSTRACT Over the past decade, the concept of “instrument constituency” has been proposed as a way in which to bridge studies on policy networks and policy instruments. This concept focuses on policy networks composed of diverse actors who are brought together by the shared goal of promoting a specific instrument.
Noémie Morize
wiley   +1 more source

Quality indicators and community pharmacy services: a scoping review. [PDF]

Int J Pharm Pract, 2019
Alhusein N, Watson MC.
europepmc   +1 more source

Comparative assessment of artificial intelligence chatbots' performance in responding to healthcare professionals' and caregivers' questions about Dravet syndrome

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence chatbots have been a game changer in healthcare, providing immediate, round‐the‐clock assistance. However, their accuracy across specific medical domains remains under‐evaluated. Dravet syndrome remains one of the most challenging epileptic encephalopathies, with new data continuously emerging in the ...
Joana Jesus‐Ribeiro, Eugenia Roza, Bárbara Oliveiros, Joana Barbosa Melo, Mar Carreño   +4 more
wiley   +1 more source

Medications used for seizure‐emergency management in the UK community: A clinical practice research datalink retrospective database study

Epilepsia Open, EarlyView.
Abstract Objective Assess the prevalence, characteristics, and healthcare resource utilization (HCRU) of patients prescribed certain benzodiazepines for seizure‐emergency management in the United Kingdom. Methods Retrospective cohort study using Clinical Practice Research Datalink (CPRD‐Aurum) and Hospital Episode Statistics (HES) data that included ...
Yuanjun Ma, Chao Lu, Peggy Hastie, Ana Paula Bartmann, Cédric Laloyaux, Simon Borghs   +5 more
wiley   +1 more source

A companion to the preclinical common data elements for rigor, reproducibility and transparency in basic and translational epilepsy research. A report of the TASK3‐WG1A: Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView.
Abstract Rigorous and transparent procedures in preclinical epilepsy research studies are important to permit assessing the reproducibility of their findings and derisk their translation into the clinic. The General Pharmacology Working Group of the ILAE/AES Task Force (TASK3‐WG1A) developed common data elements (CDEs) addressing rigor and transparency
Brian D. Klein, Lauren Harte‐Hargrove, Wenzhu Mowrey, Aristea S. Galanopoulou, Cameron S. Metcalf, Lisa Coles, Patrick A. Forcelli, Anna‐Maria Katsarou, Rudiger Koehling, Karine Leclercq, Heidrun Potschka, TASK3‐WG1A working group   +11 more
wiley   +1 more source