Results 1 to 10 of about 1,569,893 (337)
Scientific Reports, 2021 Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. While cognitive deficits remain the major manifestation of AD, metabolic and non-cognitive abnormalities, such as alterations in food intake, body
Lucas Zangerolamo +7 more
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Scientific Reports, 2021 Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream.
Gabriela Alves Bronczek +9 more
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The bile acid TUDCA reduces age-related hyperinsulinemia in mice
Scientific Reports, 2022 Aging is associated with glucose metabolism disturbances, such as insulin resistance and hyperinsulinemia, which contribute to the increased prevalence of type 2 diabetes (T2D) and its complications in the elderly population.
Lucas Zangerolamo +6 more
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Scientific Reports, 2021 Obesity and high-fat diet (HFD) consumption result in hypothalamic inflammation and metabolic dysfunction. While the TLR4 activation by dietary fats is a well-characterized pathway involved in the neuronal and glial inflammation, the role of its ...
Alexandre Moura-Assis +6 more
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Insights by which TUDCA is a potential therapy against adiposity
Frontiers in Endocrinology, 2023 Adipose tissue is an organ with metabolic and endocrine activity. White, brown and ectopic adipose tissues have different structure, location, and function.
Israelle Netto Freitas +10 more
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Saudi Pharmaceutical Journal, 2021 The medicinal uses of Calotropis procera are diverse, yet some of them are based on effects that still lack scientific support. Control of diabetes is one of them. Recently, latex proteins from C.
Keciany Alves de Oliveira +12 more
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Frontiers in Veterinary Science, 2021 Currently, experimental animals are widely used in biological and medical research. However, the scientific community has raised several bioethical concerns, such as the number of animals required to achieve reproducible and statistically relevant ...
Carlos Poblete Jara +21 more
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Aging Reduces Insulin Clearance in Mice
Frontiers in Endocrinology, 2021 Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since insulin secretion and clearance decline with age, hyperinsulinemia seems to be maintained, primarily, due to a decrease in the insulin clearance.
Carine Marmentini +8 more
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Perivascular macrophages in high-fat diet-induced hypothalamic inflammation
Journal of Neuroinflammation, 2022 Brain macrophages and microglia are centrally involved in immune surveillance of the central nervous system. Upon inflammatory stimuli, they become reactive and release key molecules to prevent further damage to the neuronal network.
Natalia F. Mendes, Licio A. Velloso
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A20 deubiquitinase controls PGC-1α expression in the adipose tissue
Lipids in Health and Disease, 2018 Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis.
Bruna Bombassaro +8 more
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