Results 91 to 100 of about 1,569,893 (337)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Comorbidities in psoriatic arthritis: a systematic review and meta-analysis

Rheumatology International, 2021
The aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations ...
Sonal Gupta, Zoe J Syrimi, D. Hughes, S. Zhao   +3 more
semanticscholar   +1 more source

Interactive CBT for headache and relaxation training (iCHART): Study protocol of a single-arm trial of interactive voice response technology delivery of cognitive-behavioral therapy for Veterans with post-traumatic headache

Cephalalgia Reports, 2023
Background: Post-traumatic headache (PTH) is persistent and highly disabling. Cognitive-behavioral therapy for headache (CBT-HA) reduces headache frequency and severity and improves people’s quality of life, yet it is underutilized and inaccessible to ...
Amy S Grinberg, Olivia Datre, Daniel G Rogers, Sarah W Clark, Stanley C Takagishi, John P Ney, Elizabeth K Seng, Brenda T Fenton, Jason J Sico   +8 more
doaj   +1 more source

Intramuscular Injection of miR-1 Reduces Insulin Resistance in Obese Mice

Frontiers in Physiology, 2021
The role of microRNAs in metabolic diseases has been recognized and modulation of them could be a promising strategy to treat obesity and obesity-related diseases.
Alice C. Rodrigues, Alexandre R. Spagnol, Flávia de Toledo Frias, Mariana de Mendonça, Hygor N. Araújo, Hygor N. Araújo, Dimitrius Guimarães, Dimitrius Guimarães, William J. Silva, Anaysa Paola Bolin, Gilson Masahiro Murata, Leonardo Silveira, Leonardo Silveira   +12 more
doaj   +1 more source

Survival Analysis of Hemodialysis Patients [PDF]

, 2016
Survival analysis as a collection of statistical procedures for analyzing the data that its outcome variable was the time to occurrence of an event. Kaplan-Meier method is a type of survival analysis technique, this method is often called the Product ...
Ardianto, E. T. (Efri), Notobroto, H. B. (Hari), Purnomo, W. (Windhu)   +2 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

KSRP improves pancreatic beta cell function and survival

Scientific Reports
Impaired insulin production and/or secretion by pancreatic beta cells can lead to high blood glucose levels and type 2 diabetes (T2D). Therefore, investigating new proteins involved in beta cell response to stress conditions could be useful in finding ...
Leticia Barssotti, Gabriela Moreira Soares, Emílio Marconato-Júnior, Bruna Lourençoni Alves, Kênia Moreno Oliveira, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Helena Cristina Lima Barbosa   +7 more
doaj   +1 more source

The impact of dietary factors on the function of brown and beige adipose tissues—implications on health and disease

Frontiers in Nutrition
The development of strategies that promote the activation of adaptive thermogenesis in brown and beige adipose tissues is expected to lead to advances in the prevention and treatment of obesity, diabetes, and cardiovascular diseases.
Bruna Bombassaro, Gabriela Batitucci, Marcela Reymond Simoes, Eliana P. Araujo, Eliana P. Araujo, Licio A. Velloso, Licio A. Velloso, Licio A. Velloso   +7 more
doaj   +1 more source

Treating substance abuse is not enough: Comorbidities in consecutively admitted female prisoners [PDF]

, 2015
Publisher Copyright: © 2015 Elsevier Ltd.Introduction: Several studies have pointed to high rates of substance use disorders among female prisoners. The present study aimed to assess comorbidities of substance use disorders with other mental disorders in
Adrian P. Mundt, Andreas Ströhle, Arntz, Binswanger, Brooke, Burling, Butler, Clarke, Compton, Daniel, Driessen, Dudeck, Fazel, Fazel, Fazel, First, Fydrich, Goldner, Gunter, Heatherton, Jacobi, Jan Mir, Johnson, Jordan, Maden, Mundt, Mundt, Norbert Konrad, Payne, Priebe, Schenk, Sheehan, Sheehan, Sinja Kastner, Steadman, Stefan Priebe, UNESCO Institute for Statistics, van den Bergh, van Emmerik-van Oortmerssen, von Schönfeld, Walmsley, Wright   +41 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source